Nguyen Vincent, Myint Janine A, Philipneri Marie
Department of Medicine, Division of Nephrology, Saint Louis University School of Medicine, Saint Louis, USA.
Cureus. 2020 Nov 22;12(11):e11633. doi: 10.7759/cureus.11633.
Purpura fulminans (PF) is a rare, life-threatening disorder characterized by disseminated intravascular coagulation (DIC), circulatory collapse, and hemorrhagic cutaneous purpura. It typically occurs secondary to acute infections, usually meningococcal septicemia, although there are also congenital and acquired causes. We report a case of a 56-year old female who presented to our institution with clinical signs of PF in the setting of acetaminophen overdose and Klebsiella pneumoniae sepsis. Given the rarity of the disease, we also review cases of PF in similar clinical scenarios that have been described in the literature.
暴发性紫癜（PF）是一种罕见的、危及生命的疾病，其特征为弥散性血管内凝血（DIC）、循环衰竭和出血性皮肤紫癜。它通常继发于急性感染，最常见的是脑膜炎球菌败血症，不过也有先天性和后天性病因。我们报告一例56岁女性患者，她在对乙酰氨基酚过量及肺炎克雷伯菌败血症的情况下，出现了暴发性紫癜的临床症状。鉴于该疾病的罕见性，我们还回顾了文献中描述的类似临床场景下的暴发性紫癜病例。
