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Burden of Proof: Evaluating the Efficacy of Tumor Mutational Burden (TMB) in Predicting Response to Immune Checkpoint Inhibitors.

作者信息

Newman James, Seetharamu Nagashree, Saif Muhammad Wasif

机构信息

Northwell Health Cancer Institute, Lake Success, NY, USA.

出版信息

Cancer Med J. 2020 Dec;3(Suppl 2):17-21. Epub 2020 Nov 19.

PMID:33377136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7769129/
Abstract
摘要

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本文引用的文献

1
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study.帕博利珠单抗治疗的晚期实体瘤患者肿瘤突变负荷与结局的相关性：多队列、开放标签、Ⅱ期 KEYNOTE-158 研究的前瞻性生物标志物分析。
Lancet Oncol. 2020 Oct;21(10):1353-1365. doi: 10.1016/S1470-2045(20)30445-9. Epub 2020 Sep 10.
2
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.纳武利尤单抗联合伊匹木单抗治疗晚期黑色素瘤的 5 年生存数据
N Engl J Med. 2019 Oct 17;381(16):1535-1546. doi: 10.1056/NEJMoa1910836. Epub 2019 Sep 28.
3
Evaluation of POLE and POLD1 Mutations as Biomarkers for Immunotherapy Outcomes Across Multiple Cancer Types.评估POLE和POLD1突变作为多种癌症类型免疫治疗结果生物标志物的研究
JAMA Oncol. 2019 Oct 1;5(10):1504-1506. doi: 10.1001/jamaoncol.2019.2963.
4
Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer.肿瘤突变负担可预测 MSI-H 转移性结直肠癌对免疫检查点抑制剂的反应。
Ann Oncol. 2019 Jul 1;30(7):1096-1103. doi: 10.1093/annonc/mdz134.
5
Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial.帕博利珠单抗对比化疗用于未经治疗、PD-L1 表达、局部晚期或转移性非小细胞肺癌（KEYNOTE-042）：一项随机、开放标签、对照、III 期临床试验。
Lancet. 2019 May 4;393(10183):1819-1830. doi: 10.1016/S0140-6736(18)32409-7. Epub 2019 Apr 4.
6
Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non-Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene Panel.利用下一代测序癌症基因 panel 评估血液肿瘤突变负担作为非小细胞肺癌患者免疫治疗的潜在生物标志物。
JAMA Oncol. 2019 May 1;5(5):696-702. doi: 10.1001/jamaoncol.2018.7098.
7
FDA Approval Summary: Pembrolizumab for the Treatment of Microsatellite Instability-High Solid Tumors.美国食品药品监督管理局批准摘要：帕博利珠单抗用于治疗微卫星高度不稳定实体瘤。
Clin Cancer Res. 2019 Jul 1;25(13):3753-3758. doi: 10.1158/1078-0432.CCR-18-4070. Epub 2019 Feb 20.
8
Tumor mutational load predicts survival after immunotherapy across multiple cancer types.肿瘤突变负荷可预测多种癌症类型免疫治疗后的生存情况。
Nat Genet. 2019 Feb;51(2):202-206. doi: 10.1038/s41588-018-0312-8. Epub 2019 Jan 14.
9
Tumor mutation burden in lung cancer: a new predictive biomarker for immunotherapy or too soon to tell?肺癌中的肿瘤突变负荷：免疫治疗的一种新的预测生物标志物，还是言之尚早？
J Thorac Dis. 2018 Nov;10(Suppl 33):S3994-S3998. doi: 10.21037/jtd.2018.09.35.
10
Methods of measurement for tumor mutational burden in tumor tissue.肿瘤组织中肿瘤突变负荷的测量方法。
Transl Lung Cancer Res. 2018 Dec;7(6):661-667. doi: 10.21037/tlcr.2018.08.02.