Department of Neonatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Pediatric Endocrine and Metabolic Diseases Laboratory, Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Asia Pac J Clin Nutr. 2020;29(4):803-812. doi: 10.6133/apjcn.202012_29(4).0016.
Neonatal nutrition is critical for the growth and development of preterm infants. Dynamic changes in the amino acid profiles in preterm infants of different gestational ages and in different nutritional periods were investigated.
Premature infants who received parenteral nutrition support after birth were enrolled and divided into four groups based on their gestational ages. Blood samples were collected as a dried blood spot before nutritional support, and in the total parenteral nutrition, partial parenteral nutrition, and total enteral nutrition periods. Amino acid concentrations were detected in the samples by liquid chromatography tandem mass spectrometry and compared between the different nutritional periods and gestational ages.
Samples from 124 premature infants were statistically analyzed. Concentrations of all amino acids, except glutamine, were statistically different at distinct nutritional periods. Threonine and aspartic acid concentrations gradually increased, while valine, methionine, phenylalanine, and glycine concentrations gradually decreased with the transition from TPN to TEN. At different gestational ages, significant differences were observed in the concentrations of seven amino acids only in the PPN period but not in the others.
The concentrations of amino acids in preterm infants vary with nutritional period.
新生儿营养对于早产儿的生长发育至关重要。本研究旨在探讨不同胎龄和不同营养期早产儿的氨基酸谱的动态变化。
本研究纳入了出生后接受肠外营养支持的早产儿，并根据胎龄将其分为四组。在营养支持前、全肠外营养、部分肠外营养和全肠内营养期间采集血样，并采用液相色谱串联质谱法检测样本中的氨基酸浓度，比较不同营养期和胎龄之间的差异。
对 124 例早产儿的样本进行了统计学分析。除谷氨酰胺外，所有氨基酸的浓度在不同的营养期均存在统计学差异。随着 TPN 向 TEN 的转变，苏氨酸和天冬氨酸的浓度逐渐增加，而缬氨酸、蛋氨酸、苯丙氨酸和甘氨酸的浓度逐渐降低。在不同胎龄组中，仅在 PPN 期观察到七种氨基酸的浓度存在显著差异，而在其他期则没有。
早产儿的氨基酸浓度随营养期而变化。
