热疗对不同大鼠组织中鸟氨酸脱羧酶活性的影响。

The effect of hyperthermia on ornithine decarboxylase activity in different rat tissues.

作者信息

Peñafiel R, Solano F, Cremades A

机构信息

Departmentos de Bioquímica y Farmacología, Facultad de Medicina, Universidad de Murcia, Spain.

出版信息

Biochem Pharmacol. 1988 Feb 1;37(3):497-502. doi: 10.1016/0006-2952(88)90220-1.

DOI:10.1016/0006-2952(88)90220-1

PMID:3337747

Abstract

Hyperthermia produced a decrease of ornithine decarboxylase activity in different tissues of adult rats. The fall in ornithine decarboxylase was dependent on time of exposure and temperature. The decay of ornithine decarboxylase activity in liver, brain, kidney, heart, spleen and testes was rather similar. The t1/2 for liver ornithine decarboxylase determined by the hyperthermic treatment (40 degrees ambient temperature) was 20 min. Ornithine decarboxylase activity was recovered in all tissues exposed to the hyperthermic shock after a period of 4 hours, although the degree of recovery was dependent on the type of tissue. The effect that hyperthermia produces on ornithine decarboxylase activity in rats could be related to an inhibition in the synthesis of active enzyme rather than to a specific degradation or inactivation of ornithine decarboxylase molecule.

摘要

高温使成年大鼠不同组织中的鸟氨酸脱羧酶活性降低。鸟氨酸脱羧酶活性的下降取决于暴露时间和温度。肝脏、大脑、肾脏、心脏、脾脏和睾丸中鸟氨酸脱羧酶活性的衰减相当相似。通过高温处理（环境温度40摄氏度）测定的肝脏鸟氨酸脱羧酶的半衰期为20分钟。在经过4小时的高温休克处理后，所有暴露于高温的组织中鸟氨酸脱羧酶活性均得以恢复，尽管恢复程度取决于组织类型。高温对大鼠鸟氨酸脱羧酶活性产生的影响可能与活性酶合成的抑制有关，而非鸟氨酸脱羧酶分子的特定降解或失活。