糖皮质激素拮抗剂RU 38486对地塞米松抗炎作用的逆转 - Suppr

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超能文献

Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486.

作者信息

Peers S H, Moon D, Flower R J

机构信息

Pharmacology Group, University of Bath, Claverton Down, U.K.

出版信息

Biochem Pharmacol. 1988 Feb 1;37(3):556-7. doi: 10.1016/0006-2952(88)90230-4.

DOI:10.1016/0006-2952(88)90230-4

PMID:3337749

Abstract

摘要

相似文献

Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486.糖皮质激素拮抗剂RU 38486对地塞米松抗炎作用的逆转

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Receptor-mediated effects of glucocorticoids on inflammation: enhancement of the inflammatory response with a glucocorticoid antagonist.糖皮质激素对炎症的受体介导效应：使用糖皮质激素拮抗剂增强炎症反应。

J Steroid Biochem. 1988 Jun;29(6):591-8. doi: 10.1016/0022-4731(88)90156-2.

Dexamethasone antagonism by RU 38,486 in inflammatory reactions of the rat and mouse. Part 1: Degree of inflammation.

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Local anti-inflammatory activities of tixocortol 21-pivalate, inhibition of prostaglandins and leukotrienes synthesis, in carrageenin-induced pleurisy. Reversion of effects by RU 486.

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Dexamethasone antagonism by RU 38486 in inflammatory reactions of the rat. Part 2: Biochemical parameters: RNA content of inflammation cells and acute phase reactants of the blood.RU 38486对大鼠炎症反应中地塞米松的拮抗作用。第2部分：生化参数：炎症细胞的RNA含量及血液中的急性期反应物

Pharmazie. 1988 May;43(5):370-1.

Effect of antiglucocorticoids on dexamethasone-induced inhibition of uridine incorporation and cell lysis in isolated mouse thymocytes.抗糖皮质激素对离体小鼠胸腺细胞中地塞米松诱导的尿苷掺入抑制及细胞裂解的影响。

J Steroid Biochem. 1984 Jan;20(1):283-7. doi: 10.1016/0022-4731(84)90218-8.

Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites.抗糖皮质激素RU 38486可减弱一种行为的记忆保持，并在不同脑区解除下丘脑-垂体-肾上腺轴的抑制。

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Blockade of glucocorticoid receptor binding and inhibition of dexamethasone-induced muscle atrophy in the rat by RU38486, a potent glucocorticoid antagonist.强效糖皮质激素拮抗剂RU38486对大鼠糖皮质激素受体结合的阻断作用及对地塞米松诱导的肌肉萎缩的抑制作用。

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Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease-susceptible Lewis rats and inflammatory disease-resistant Fischer rats.糖皮质激素和/或糖皮质激素拮抗剂对易患炎症性疾病的刘易斯大鼠和抗炎症性疾病的费希尔大鼠的影响。

Endocrinology. 1995 Jul;136(7):3107-12. doi: 10.1210/endo.136.7.7789338.

RU 486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day.RU 486：一种具有抗糖皮质激素活性的类固醇，仅在一天中的特定时间解除对人体垂体 - 肾上腺系统的抑制作用。

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