• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486.

作者信息

Peers S H, Moon D, Flower R J

机构信息

Pharmacology Group, University of Bath, Claverton Down, U.K.

出版信息

Biochem Pharmacol. 1988 Feb 1;37(3):556-7. doi: 10.1016/0006-2952(88)90230-4.

DOI:10.1016/0006-2952(88)90230-4
PMID:3337749
Abstract
摘要

相似文献

1
Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486.糖皮质激素拮抗剂RU 38486对地塞米松抗炎作用的逆转
Biochem Pharmacol. 1988 Feb 1;37(3):556-7. doi: 10.1016/0006-2952(88)90230-4.
2
Receptor-mediated effects of glucocorticoids on inflammation: enhancement of the inflammatory response with a glucocorticoid antagonist.糖皮质激素对炎症的受体介导效应：使用糖皮质激素拮抗剂增强炎症反应。
J Steroid Biochem. 1988 Jun;29(6):591-8. doi: 10.1016/0022-4731(88)90156-2.
3
Dexamethasone antagonism by RU 38,486 in inflammatory reactions of the rat and mouse. Part 1: Degree of inflammation.
Pharmazie. 1988 Mar;43(3):219-20.
4
Local anti-inflammatory activities of tixocortol 21-pivalate, inhibition of prostaglandins and leukotrienes synthesis, in carrageenin-induced pleurisy. Reversion of effects by RU 486.
Agents Actions. 1988 Jun;24(1-2):172-8. doi: 10.1007/BF01968097.
5
Dexamethasone antagonism by RU 38486 in inflammatory reactions of the rat. Part 2: Biochemical parameters: RNA content of inflammation cells and acute phase reactants of the blood.RU 38486对大鼠炎症反应中地塞米松的拮抗作用。第2部分：生化参数：炎症细胞的RNA含量及血液中的急性期反应物
Pharmazie. 1988 May;43(5):370-1.
6
Effect of antiglucocorticoids on dexamethasone-induced inhibition of uridine incorporation and cell lysis in isolated mouse thymocytes.抗糖皮质激素对离体小鼠胸腺细胞中地塞米松诱导的尿苷掺入抑制及细胞裂解的影响。
J Steroid Biochem. 1984 Jan;20(1):283-7. doi: 10.1016/0022-4731(84)90218-8.
7
Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites.抗糖皮质激素RU 38486可减弱一种行为的记忆保持，并在不同脑区解除下丘脑-垂体-肾上腺轴的抑制。
Neuroendocrinology. 1988 Feb;47(2):109-15. doi: 10.1159/000124900.
8
Blockade of glucocorticoid receptor binding and inhibition of dexamethasone-induced muscle atrophy in the rat by RU38486, a potent glucocorticoid antagonist.强效糖皮质激素拮抗剂RU38486对大鼠糖皮质激素受体结合的阻断作用及对地塞米松诱导的肌肉萎缩的抑制作用。
Endocrinology. 1986 Jul;119(1):375-80. doi: 10.1210/endo-119-1-375.
9
Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease-susceptible Lewis rats and inflammatory disease-resistant Fischer rats.糖皮质激素和/或糖皮质激素拮抗剂对易患炎症性疾病的刘易斯大鼠和抗炎症性疾病的费希尔大鼠的影响。
Endocrinology. 1995 Jul;136(7):3107-12. doi: 10.1210/endo.136.7.7789338.
10
RU 486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day.RU 486：一种具有抗糖皮质激素活性的类固醇，仅在一天中的特定时间解除对人体垂体 - 肾上腺系统的抑制作用。
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3879-82. doi: 10.1073/pnas.81.12.3879.

引用本文的文献

1
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.氧化应激、激素与天然抗氧化剂对炎症性肠病肠道炎症的影响。
Front Endocrinol (Lausanne). 2023 Aug 28;14:1217165. doi: 10.3389/fendo.2023.1217165. eCollection 2023.
2
Hormonal control of inflammatory responses.激素对炎症反应的调控。
Mediators Inflamm. 1993;2(3):181-98. doi: 10.1155/S0962935193000250.
3
Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo.
格尔德霉素是一种热休克蛋白90（Hsp90）介导的信号转导抑制剂，具有抗炎作用，并在体内与糖皮质激素受体相互作用。
Br J Pharmacol. 2000 Sep;131(1):13-6. doi: 10.1038/sj.bjp.0703549.
4
Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation.通过流式细胞术测定小鼠外周血白细胞中脂皮质素1水平：糖皮质激素和炎症的调节作用
Br J Pharmacol. 1996 Jun;118(3):605-10. doi: 10.1111/j.1476-5381.1996.tb15444.x.
5
Regulation of tumour necrosis factor production by adrenal hormones in vivo: insights into the antiinflammatory activity of rolipram.体内肾上腺激素对肿瘤坏死因子产生的调节：对咯利普兰抗炎活性的见解。
Br J Pharmacol. 1996 Apr;117(7):1530-4. doi: 10.1111/j.1476-5381.1996.tb15317.x.
6
Development of specific antibody and in vivo response to antigen in different rat strains: effect of dexamethasone and importance of endogenous corticosteroids.不同大鼠品系中特异性抗体的产生及对抗原的体内反应：地塞米松的作用及内源性皮质类固醇的重要性
Agents Actions. 1993 Jul;39(3-4):174-81. doi: 10.1007/BF01998971.
7
Serum corticosterone, interleukin-1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains.大鼠实验性内毒素血症中的血清皮质酮、白细胞介素-1和肿瘤坏死因子：Lewis和Wistar品系的比较
Br J Pharmacol. 1993 Oct;110(2):868-74. doi: 10.1111/j.1476-5381.1993.tb13893.x.
8
Inhibition of some aspects of acute inflammation of guinea-pig lung by intraperitoneal dexamethasone and mifepristone: demonstration of agonist activity of mifepristone in the guinea-pig.腹腔注射地塞米松和米非司酮对豚鼠肺急性炎症某些方面的抑制作用：米非司酮在豚鼠体内激动剂活性的证明
Inflamm Res. 1995 Mar;44(3):131-8. doi: 10.1007/BF01782024.
9
A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasone.内源性组胺在白细胞介素-8诱导的中性粒细胞浸润小鼠气囊肿中的作用：全身性和局部地塞米松调节作用的研究
Br J Pharmacol. 1994 Jul;112(3):801-8. doi: 10.1111/j.1476-5381.1994.tb13150.x.
10
Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.内源性糖皮质激素对一氧化氮合酶诱导的减弱是体内内毒素耐受的原因。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):271-5. doi: 10.1073/pnas.91.1.271.