Peers S H, Duncan G S, Flower R J
Department of Biochemical Pharmacology, William Harvey Research Institute, St. Bartholomew's Medical College, London.
Agents Actions. 1993 Jul;39(3-4):174-81. doi: 10.1007/BF01998971.
Endogenous glucocorticoids undoubtedly play a role in the control of immune responses: their contribution to inter-strain variation is unknown. The development of specific IgG and IgE was measured following inoculation with ovalbumin in Lewis, Fischer, Wistar and Brown Norway rats. The Lewis gives a smaller IgG and IgE response than the other strains and the response in vivo to antigen injected into the paw correlates with the titre of specific antibody. Treatment with the steroid receptor antagonist RU486 (mifepristone) following inoculation reveals that in the Lewis, and to a lesser extent in the Brown Norway, the development of a specific IgG response is limited by endogenous corticosteroids. The IgG response in different strains is differently sensitive to treatment with the synthetic glucocorticoid dexamethasone, the Lewis being particularly resistant. The importance of control by endogenous corticosteroids should not be overlooked in contributing to strain differences in immune response.
其对品系间差异的影响尚不清楚。在给Lewis、Fischer、Wistar和棕色挪威大鼠接种卵清蛋白后，检测了特异性IgG和IgE的产生情况。Lewis大鼠产生的IgG和IgE反应比其他品系小，并且体内对注射到爪中的抗原的反应与特异性抗体的滴度相关。接种后用类固醇受体拮抗剂RU486（米非司酮）治疗表明，在Lewis大鼠中，以及在棕色挪威大鼠中程度较轻的情况下，特异性IgG反应的产生受到内源性皮质类固醇的限制。不同品系的IgG反应对合成糖皮质激素地塞米松的治疗敏感性不同，Lewis大鼠尤其耐药。在导致免疫反应的品系差异方面，内源性皮质类固醇的调控作用不应被忽视。
