Robert J A, Romero R, Costigan K
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Am J Perinatol. 1988 Jan;5(1):26-8. doi: 10.1055/s-2007-999647.
A cohort study with four groups of pregnant women was designed to evaluate if a decrease in the concentration of fibronectin (FN) in amniotic fluid plays a role in the genesis of premature rupture of the membranes (PROM) and/or intra-amniotic infection: group 1, 15 patients with PROM and intra-amniotic infection; group 2, 15 patients with PROM but without intra-amniotic infection; group 3, 15 patients with preterm labor without PROM or intra-amniotic infection; and group 4, 15 patients who underwent elective amniocentesis for fetal lung maturity studies. No significant differences in amniotic fluid concentrations of FN among any of the four groups was observed (F = 0.146; P = 0.931). These results suggest that a deficiency of FN in amniotic fluid is not a critical factor in determining which patients may be affected by PROM or which of them will develop an intra-amniotic infection.
一项针对四组孕妇的队列研究旨在评估羊水纤连蛋白（FN）浓度降低是否在胎膜早破（PROM）和/或羊膜腔内感染的发生中起作用：第1组，15例患有PROM和羊膜腔内感染的患者；第2组，15例患有PROM但无羊膜腔内感染的患者；第3组，15例有早产但无PROM或羊膜腔内感染的患者；第4组，15例因胎儿肺成熟研究而接受选择性羊膜穿刺术的患者。四组中任何一组的羊水FN浓度均未观察到显著差异（F = 0.146；P = 0.931）。这些结果表明，羊水FN缺乏不是决定哪些患者可能受PROM影响或哪些患者会发生羊膜腔内感染的关键因素。
