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趋化因子受体淋巴细胞激活素受体 1 的过表达对肾透明细胞癌有预后价值。

Overexpression of chemokine receptor lymphotactin receptor 1 has prognostic value in clear cell renal cell carcinoma.

机构信息

Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University, Chongqing, P. R. China.

Department of Pathology, Xinqiao Hospital, Third Military Medical University (Army Medical University, Chongqing, P. R. China.

出版信息

Mol Genet Genomic Med. 2021 Jan;9(1):e1551. doi: 10.1002/mgg3.1551. Epub 2020 Dec 30.

DOI:10.1002/mgg3.1551
PMID:33377624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7963425/
Abstract

BACKGROUND

Clear cell renal cell carcinoma (ccRCC) is an aggressive subtype of renal cell carcinoma. X-C motif chemokine receptor 1 (XCR1) exerts important roles in tumor progression; however, its role in ccRCC is unclear.

METHODS

We utilized publicly available data from The Cancer Genome Atlas (TCGA) to assess the role of XCR1 in ccRCC and validated the results in 36 samples from patients with ccRCC who underwent curative resection in Xinqiao Hospital Chongqing. XCR1 overexpression was identified in ccRCC, which was confirmed by qRT-PCR assay and immunohistochemical staining of ccRCC samples.

RESULTS

For the TCGA and clinical data, Kaplan-Meier survival analysis revealed that higher XCR1 expression in ccRCC was related to longer overall survival. Cox regression analysis suggested that XCR1 is an independent risk factor for ccRCC. GSEA analysis suggested that XCR1 is associated with the JAK/STAT signaling pathway. XCR1 knockdown by small interfering RNA (siRNA) significantly increased ccRCC cell proliferation and migration, and decreased cell apoptosis.

CONCLUSION

We found higher XCR1 expression in ccRCC compared with that in normal tissues is related to longer overall survival in patients with ccRCC. XCR1 knockdown significantly increased RCC cells proliferation and migration, and decreased apoptosis. XCR1 might be used as a prognostic biomarker in ccRCC in the future.

摘要

背景

透明细胞肾细胞癌（ccRCC）是肾细胞癌的一种侵袭性亚型。X-C 基序趋化因子受体 1（XCR1）在肿瘤进展中发挥重要作用；然而，其在 ccRCC 中的作用尚不清楚。

方法

我们利用癌症基因组图谱（TCGA）中的公开数据评估 XCR1 在 ccRCC 中的作用，并在新桥医院重庆 36 例接受根治性切除术的 ccRCC 患者的样本中验证了结果。通过 qRT-PCR 检测和 ccRCC 样本的免疫组织化学染色，确定了 XCR1 在 ccRCC 中的过表达。

结果

对于 TCGA 和临床数据，Kaplan-Meier 生存分析显示，ccRCC 中 XCR1 表达水平较高与总生存期延长相关。Cox 回归分析表明，XCR1 是 ccRCC 的独立危险因素。GSEA 分析表明，XCR1 与 JAK/STAT 信号通路有关。用小干扰 RNA（siRNA）敲低 XCR1 显著增加了 ccRCC 细胞的增殖和迁移，并减少了细胞凋亡。

结论

与正常组织相比，ccRCC 中 XCR1 表达水平较高与 ccRCC 患者的总生存期延长有关。XCR1 敲低显著增加了 RCC 细胞的增殖和迁移，并减少了凋亡。XCR1 可能成为未来 ccRCC 的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/9711227a9a73/MGG3-9-e1551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/fc4f47860d1e/MGG3-9-e1551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/acc73dcc112a/MGG3-9-e1551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/95931bfca166/MGG3-9-e1551-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/4b741767e54b/MGG3-9-e1551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/9711227a9a73/MGG3-9-e1551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/fc4f47860d1e/MGG3-9-e1551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/acc73dcc112a/MGG3-9-e1551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/95931bfca166/MGG3-9-e1551-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/4b741767e54b/MGG3-9-e1551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bd/7963425/9711227a9a73/MGG3-9-e1551-g001.jpg

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