抑制肌醇单磷酸酶并降低肌醇浓度可改善骨骼肌萎缩。 - Suppr

Inhibited inositol monophosphatase and decreased myo-inositol concentration improve wasting in skeletal muscles.

作者信息

Lee Ji-Hyung, Kim Hyun-Jun, Kim Seon-Wook, Um JungIn, Jung Da-Woon, Williams Darren R

机构信息

New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

出版信息

Clin Transl Med. 2020 Dec;10(8):e251. doi: 10.1002/ctm2.251.

DOI:10.1002/ctm2.251

PMID:33377657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7724229/

Abstract

摘要

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Inhibited inositol monophosphatase and decreased myo-inositol concentration improve wasting in skeletal muscles.抑制肌醇单磷酸酶并降低肌醇浓度可改善骨骼肌萎缩。

Clin Transl Med. 2020 Dec;10(8):e251. doi: 10.1002/ctm2.251.

Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.

Neurosci Lett. 1998 Apr 10;245(3):159-62. doi: 10.1016/s0304-3940(98)00209-2.

Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.铍竞争性抑制脑肌醇单磷酸酶，但与锂不同的是，它不会增强激动剂诱导的肌醇磷酸积累。

Biochem J. 1993 Apr 15;291 ( Pt 2)(Pt 2):369-74. doi: 10.1042/bj2910369.

Myo-inositol monophosphatase: diverse effects of lithium, carbamazepine, and valproate.肌醇单磷酸酶：锂盐、卡马西平和丙戊酸盐的不同作用

Neuropsychopharmacology. 1995 Jul;12(4):277-85. doi: 10.1016/0893-133X(94)00088-H.

Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.结核分枝杆菌SuhB的纯化及生化特性分析，SuhB是一种参与肌醇生物合成的肌醇单磷酸酶。

Biochemistry. 2002 Apr 2;41(13):4392-8. doi: 10.1021/bi0160056.

Noncompetitive inhibition of inositol monophosphatase by K-76 monocarboxylic acid.K-76单羧酸对肌醇单磷酸酶的非竞争性抑制作用。

Mol Pharmacol. 1991 Jul;40(1):107-11.

Characterization of the inositol monophosphatase gene family in Arabidopsis.拟南芥肌醇单磷酸酶基因家族的特征分析

Front Plant Sci. 2015 Jan 9;5:725. doi: 10.3389/fpls.2014.00725. eCollection 2014.

myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity.大脑中的肌醇单磷酸酶具有锌离子依赖性酪氨酸磷酸酶活性。

Gen Pharmacol. 1998 Sep;31(3):469-75. doi: 10.1016/s0306-3623(98)00006-8.

Chronically administered lithium alters neither myo-inositol monophosphatase activity nor phosphoinositide levels in rat brain.

J Neurochem. 1989 Aug;53(2):590-4. doi: 10.1111/j.1471-4159.1989.tb07374.x.

Production of myo-inositol from glucose by a novel trienzymatic cascade of polyphosphate glucokinase, inositol 1-phosphate synthase and inositol monophosphatase.新型多聚磷酸葡萄糖激酶、肌醇 1-磷酸合酶和肌醇单磷酸酶三酶级联反应从葡萄糖生产肌醇。

Enzyme Microb Technol. 2018 May;112:1-5. doi: 10.1016/j.enzmictec.2018.01.006. Epub 2018 Jan 31.

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Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression.用BML-260调节磷酸酶DUSP22可通过不依赖Akt的JNK-FOXO3a抑制改善骨骼肌萎缩。

EMBO Mol Med. 2025 Apr 22. doi: 10.1038/s44321-025-00234-2.

Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia.年龄只是一个数字：肌少症新候选药物发现的进展和障碍。

Cells. 2023 Nov 11;12(22):2608. doi: 10.3390/cells12222608.

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An Overview of Muscle Atrophy.肌肉萎缩概述。

Adv Exp Med Biol. 2018;1088:3-19. doi: 10.1007/978-981-13-1435-3_1.

Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation.通过下调 SIRT3，骨质疏松症药物阿仑膦酸钠在体外和肌肉疾病模型中预防肌肉减少症。

J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):585-602. doi: 10.1002/jcsm.12289. Epub 2018 Mar 6.

Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.肌醇可降低肺癌化学预防小鼠模型中的 IL-6 水平和肿瘤相关磷酸化 STAT3，从而减少肿瘤发生。

Int J Cancer. 2018 Apr 1;142(7):1405-1417. doi: 10.1002/ijc.31152. Epub 2017 Dec 23.

Lessons from the swamp: developing small molecules that confer salamander muscle cellularization in mammals.沼泽中的启示：开发能使哺乳动物实现蝾螈肌肉细胞化的小分子。

Clin Transl Med. 2017 Dec;6(1):13. doi: 10.1186/s40169-017-0143-8. Epub 2017 Mar 22.

Some leopards can change their spots: potential repositioning of stem cell reprogramming compounds as anti-cancer agents.有些豹能改变身上的斑点：干细胞重编程化合物作为抗癌药物的潜在重新定位。

Cell Biol Toxicol. 2016 Jun;32(3):157-68. doi: 10.1007/s10565-016-9333-1. Epub 2016 May 8.

No longer going to waste.不再浪费。

Nat Biotechnol. 2016 May 6;34(5):458-61. doi: 10.1038/nbt.3557.

Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway.p53-ISYNA1途径对肌醇生物合成的调控

Int J Oncol. 2016 Jun;48(6):2415-24. doi: 10.3892/ijo.2016.3456. Epub 2016 Mar 24.

Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent.哺乳动物肌醇-3-磷酸合酶：其在脑肌醇生物合成中的作用及其作为精神活性药物的临床应用。

Subcell Biochem. 2006;39:293-314. doi: 10.1007/0-387-27600-9_12.

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.Foxo转录因子诱导与萎缩相关的泛素连接酶atrogin-1并导致骨骼肌萎缩。

Cell. 2004 Apr 30;117(3):399-412. doi: 10.1016/s0092-8674(04)00400-3.

High uptake of myo-inositol by rat pancreatic tissue in vitro stimulates secretion.

J Biol Chem. 1976 Aug 25;251(16):5078-86.

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Inhibited inositol monophosphatase and decreased myo-inositol concentration improve wasting in skeletal muscles.

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