Klinik für Innere Medizin IV, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.
Klinik für Innere Medizin IV, Nieren- und Hochdruckkrankheiten, Universitätsklinikum des Saarlandes, Kirrberger Straße, Gebäude 41, 66421, Homburg/Saar, Germany.
Herz. 2021 Jun;46(3):206-211. doi: 10.1007/s00059-020-05012-z. Epub 2020 Dec 30.
Chronic kidney disease (CKD) is associated with substantial cardiovascular morbidity and mortality. This is mediated by highly prevalent traditional cardiovascular risk factors such as arterial hypertension and diabetes mellitus in patients with CKD, but also by the presence of CKD-specific so-called nontraditional cardiovascular risk factors such as vascular calcification, uremic toxins, uremic dyslipidemia, inflammation, and oxidative stress. Therefore, the primary and secondary prevention of cardiovascular disease represents an important part of the care of patients with CKD. This entails optimal control of blood pressure and diabetes, treatment of the uremic dyslipidemia, as well as life-style modifying factors such as weight reduction and smoking cessation.
慢性肾脏病（CKD）与大量心血管发病率和死亡率相关。这是由 CKD 患者中普遍存在的传统心血管危险因素（如动脉高血压和糖尿病），以及 CKD 特有的所谓非传统心血管危险因素（如血管钙化、尿毒症毒素、尿毒症血脂异常、炎症和氧化应激）介导的。因此，心血管疾病的一级和二级预防是 CKD 患者治疗的重要组成部分。这需要优化血压和糖尿病的控制，治疗尿毒症血脂异常，以及生活方式改变因素，如减肥和戒烟。
