Department of Physiology, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Nigeria.
Andrologia. 2021 Mar;53(2):e13931. doi: 10.1111/and.13931. Epub 2020 Dec 30.
Sexual activity is an essential part of reproductive functions and needed for the maintenance of fertility. Drugs, particularly substances of abuse, impair male reproductive function either by interrupting hormonal functions or through the nonhormonal pathways. This study evaluated the impact of Rohypnol use in sexual behaviour. Materials and methods: Thirty adult male Wistar rats of comparable weights (180-200 g) were randomly allocated into three groups, the control and low-dose and high-dose Rohypnol-treated groups. The control group received 0.5 ml of distilled water, while the low- and high-dose Rohypnol-treated groups received 2 mg/kg b.w and 4 mg/kg b.w of Rohypnol via oral lavage once daily for 28 days. Rohypnol significantly increased mount latency, intromission latency, ejaculation latency and post-ejaculatory interval, as well as lowered mount frequency, intromission frequency and ejaculation frequency. Rohypnol-induced sexual dysfunction was found to be associated with significant suppression of circulatory follicle-stimulating hormone, luteinising hormone, testosterone and oestrogen. The present study reveals that Rohypnol induces sexual dysfunction through suppression of hypothalamic-pituitary-testicular axis. It also implicates Rohypnol as a potential candidate for drug-induced infertility.
性行为是生殖功能的重要组成部分，对于维持生育能力是必需的。药物，特别是滥用物质，通过中断激素功能或通过非激素途径损害男性生殖功能。本研究评估了罗眠乐对性行为的影响。
将 30 只成年雄性 Wistar 大鼠按体重（180-200g）随机分为三组，对照组和低剂量及高剂量罗眠乐处理组。对照组给予 0.5ml 蒸馏水，低剂量和高剂量罗眠乐处理组通过灌胃分别给予 2mg/kg b.w 和 4mg/kg b.w 的罗眠乐，每日一次，共 28 天。
罗眠乐显著增加了勃起潜伏期、插入潜伏期、射精潜伏期和射精后间隔时间，同时降低了勃起频率、插入频率和射精频率。罗眠乐引起的性功能障碍与循环促卵泡激素、黄体生成素、睾酮和雌激素的显著抑制有关。
本研究表明，罗眠乐通过抑制下丘脑-垂体-睾丸轴引起性功能障碍。它还暗示罗眠乐可能是一种潜在的药物引起不孕的候选药物。
