Cancer Registry Zurich, Zug, Schaffhausen and Schwyz, Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland / Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Cancer Registry Zurich, Zug, Schaffhausen and Schwyz, Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Swiss Med Wkly. 2020 Dec 14;150:w20388. doi: 10.4414/smw.2020.20388.
The Cancer Registry Zurich, Zug, Schaffhausen and Schwyz is one of the oldest cancer registries in Switzerland, first registering tumours in 1980 for the canton of Zurich. The aim of this study was to analyse trends in incidence and mortality for the most common types of cancer in the canton of Zurich from 1981 to 2017.
In this analysis of population-based cancer registry data, we included malignant tumours of the breast (ICD10 C50), prostate (C61), colon/rectum (C18–C21), lung (C33–C34), and melanoma (C43), diagnosed between 1981 and 2017. Age-standardised incidence and mortality rates per 100,000 person-years were computed using the 1976 European Standard Population. Incidence and mortality time trends were assessed using joinpoint regression analysis.
In men, incidence for prostate cancer and melanoma increased over the study period, while it decreased for colon/rectum and lung cancer. A joinpoint for prostate cancer indicated the start of a decreasing trend in 2002. In women, incidence increased for breast cancer, lung cancer and melanoma; no trend was observed for colon/rectum cancer. Cancer mortality decreased for prostate, colon/rectum and lung cancer in men, with no clear trend for melanoma. In women, mortality decreased for breast cancer, colon/rectum cancer and melanoma, but increased for lung cancer.
The overall increasing incidence trends for prostate and breast cancer, as well as for melanoma, are in line with data from other Western countries. While lung cancer incidence is decreasing in men, it is still on the rise in women. Despite increasing incidence rates, mortality rates are decreasing for all localisations except for lung cancer in women. The opposite direction of incidence and mortality curves is probably mostly due to better and more effective treatment options, as well as earlier detection.
苏黎世、楚格、沙夫豪森和施维茨癌症登记处是瑞士最古老的癌症登记处之一，于 1980 年首次为苏黎世州登记肿瘤。本研究的目的是分析 1981 年至 2017 年苏黎世州最常见癌症类型的发病率和死亡率趋势。
在这项基于人群的癌症登记处数据分析中，我们纳入了 1981 年至 2017 年间诊断的乳腺（ICD10 C50）、前列腺（C61）、结肠/直肠（C18-C21）、肺（C33-C34）和黑色素瘤（C43）恶性肿瘤。使用 1976 年欧洲标准人口计算每 10 万人年的标准化发病率和死亡率。使用 joinpoint 回归分析评估发病率和死亡率的时间趋势。
在男性中，前列腺癌和黑色素瘤的发病率在研究期间有所上升，而结肠/直肠和肺癌的发病率则有所下降。前列腺癌的一个 joinpoint 表明，2002 年开始出现下降趋势。在女性中，乳腺癌、肺癌和黑色素瘤的发病率有所上升；结肠/直肠癌没有明显的趋势。男性前列腺癌、结肠/直肠癌和肺癌的癌症死亡率下降，黑色素瘤则没有明显的趋势。在女性中，乳腺癌、结肠/直肠癌和黑色素瘤的死亡率下降，但肺癌的死亡率上升。
与其他西方国家的数据一致，前列腺癌和乳腺癌以及黑色素瘤的总体发病率上升趋势。虽然男性肺癌的发病率在下降，但女性的发病率仍在上升。尽管发病率上升，但除了女性的肺癌外，所有部位的死亡率都在下降。发病率和死亡率曲线的相反方向可能主要是由于更好和更有效的治疗选择以及更早的检测。
