Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Veneto Tumour Registry, Azienda Zero, Padua, Italy.
Front Public Health. 2024 Jan 8;11:1267534. doi: 10.3389/fpubh.2023.1267534. eCollection 2023.
This observational study considers the sex-specific incidence of the most incident cancers as recorded in the population-based Veneto Regional Cancer Registry over a period of more than 30 years (1987-2019).
The Veneto Regional Cancer Registry collected data for the time interval 1987-2019. Significant changes in incidence trends calculated on age-standardized incidence rates (Annual Percent Change-APC) were identified by join point regression analysis.
Overall, the incidence trend for all cancers decreased in males and remained stable in females. In nine cancer sites, the incidence trends showed consistent differences by sex (oral cavity, esophagus, colon rectum and anus, liver, larynx, lung, cutaneous malignant melanoma, bladder, and thyroid gland). Other malignancies did not show significant sex-related differences (stomach, pancreas, biliary tract, kidney/urinary tract, central nervous system, multiple myeloma, non-Hodgkin lymphoma, and leukemia).
In the period 1987-2019, this study revealed sex-related differences in cancer incidence trends. Over time, cancer incidence remained higher in males, with a decreasing epidemiological impact, plausibly resulting from prevention campaigns against environmental cancer risk factors, as tobacco and alcohol. Conversely, a significant decrease was not observed in the incidence trend in females. These findings contribute essential insights for profiling the epidemiological map of cancer in a large Italian population, allowing comparison with other European cancer epidemiology studies and providing updated data supporting sex-related primary and secondary cancer prevention strategies.
本观察性研究考虑了在人口基础上的威尼托地区癌症登记处超过 30 年（1987-2019 年）期间记录的最常见癌症的性别特异性发病率。
威尼托地区癌症登记处收集了 1987-2019 年期间的数据。通过连接点回归分析确定了按年龄标准化发病率（年百分比变化-APC）计算的发病率趋势的显著变化。
总体而言，男性所有癌症的发病率趋势下降，而女性则保持稳定。在九个癌症部位，发病率趋势存在性别差异（口腔、食管、结肠直肠和肛门、肝脏、喉、肺、皮肤恶性黑色素瘤、膀胱和甲状腺）。其他恶性肿瘤没有表现出显著的性别差异（胃、胰腺、胆道、肾脏/泌尿系统、中枢神经系统、多发性骨髓瘤、非霍奇金淋巴瘤和白血病）。
在 1987-2019 年期间，本研究揭示了癌症发病率趋势的性别差异。随着时间的推移，癌症发病率在男性中仍然较高，其流行病学影响呈下降趋势，这可能是由于针对环境癌症危险因素（如烟草和酒精）的预防运动的结果。相反，女性的发病率趋势没有观察到显著下降。这些发现为在一个大型意大利人群中描绘癌症的流行病学图谱提供了重要的见解，允许与其他欧洲癌症流行病学研究进行比较，并提供支持基于性别的一级和二级癌症预防策略的更新数据。
