Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland.
Transfaculty Research Platform Molecular and Cognitive Neurosciences (MCN), University of Basel, Basel, Switzerland.
J Pineal Res. 2021 Apr;70(3):e12714. doi: 10.1111/jpi.12714. Epub 2021 Jan 18.
We examined whether dynamically changing light across a scheduled 16-h waking day influences sleepiness, cognitive performance, visual comfort, melatonin secretion, and sleep under controlled laboratory conditions in healthy men. Fourteen participants underwent a 49-h laboratory protocol in a repeated-measures study design. They spent the first 5 hours in the evening under standard lighting, followed by an 8-h nocturnal sleep episode at habitual bedtimes. Thereafter, volunteers either woke up to static light or to a dynamic light that changed spectrum and intensity across the scheduled 16-h waking day. Following an 8-h nocturnal sleep episode, the volunteers spent another 11 hours either under static or dynamic light. Static light attenuated the evening rise in melatonin levels more compared to dynamic light as indexed by a significant reduction in the melatonin AUC prior to bedtime during static light only. Participants felt less vigilant in the evening during dynamic light. After dynamic light, sleep latency was significantly shorter in both the baseline and treatment night while sleep structure, sleep quality, cognitive performance, and visual comfort did not significantly differ. The study shows that dynamic changes in spectrum and intensity of light promote melatonin secretion and sleep initiation in healthy men.
我们在受控的实验室条件下，研究了在 16 小时清醒日期间动态变化的光照是否会影响健康男性的困倦感、认知表现、视觉舒适度、褪黑素分泌和睡眠。14 名参与者在重复测量研究设计的 49 小时实验室方案中进行了研究。他们在晚上的前 5 小时处于标准照明下，然后按照习惯的就寝时间进行 8 小时夜间睡眠。此后，志愿者要么在静态光下醒来，要么在动态光下醒来，这种动态光在预定的 16 小时清醒日期间会改变光谱和强度。在 8 小时夜间睡眠后，志愿者在静态或动态光下再度过 11 小时。与动态光相比，静态光更能抑制褪黑素水平在晚上的升高，这表现在仅在静态光下，入睡前褪黑素 AUC 显著减少。与动态光相比，参与者在晚上感觉警觉性较低。在动态光之后，无论是在基线夜还是在治疗夜，睡眠潜伏期都明显缩短，而睡眠结构、睡眠质量、认知表现和视觉舒适度没有显著差异。该研究表明，光的光谱和强度的动态变化可促进健康男性的褪黑素分泌和睡眠起始。
