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肿瘤中免疫抑制性巨噬细胞的不同群体来源于单核细胞来源的髓系抑制细胞。

Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer.

机构信息

The Wistar Institute, Philadelphia, PA 19104, USA.

Tara Miller Melanoma Center, Abramson Cancer Center and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Cell Rep. 2020 Dec 29;33(13):108571. doi: 10.1016/j.celrep.2020.108571.

DOI:10.1016/j.celrep.2020.108571
PMID:33378668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7809772/
Abstract

Here, we report that functional heterogeneity of macrophages in cancer could be determined by the nature of their precursors: monocytes (Mons) and monocytic myeloid-derived suppressor cells (M-MDSCs). Macrophages that are differentiated from M-MDSCs, but not from Mons, are immune suppressive, with a genomic profile matching that of M-MDSCs. Immune-suppressive activity of M-MDSC-derived macrophages is dependent on the persistent expression of S100A9 protein in these cells. S100A9 also promotes M2 polarization of macrophages. Tissue-resident- and Mon-derived macrophages lack expression of this protein. S100A9-dependent immune-suppressive activity of macrophages involves transcription factor C/EBPβ. The presence of S100A9-positive macrophages in tumor tissues is associated with shorter survival in patients with head and neck cancer and poor response to PD-1 antibody treatment in patients with metastatic melanoma. Thus, this study reveals the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.

摘要

在这里，我们报告称，巨噬细胞的功能异质性可以由其前体细胞的性质决定：单核细胞（Mons）和单核细胞来源的髓系抑制细胞（M-MDSCs）。从 M-MDSCs 而不是 Mons 分化而来的巨噬细胞具有免疫抑制作用，其基因组图谱与 M-MDSCs 匹配。M-MDSC 衍生的巨噬细胞的免疫抑制活性依赖于这些细胞中 S100A9 蛋白的持续表达。S100A9 还促进巨噬细胞向 M2 极化。组织驻留巨噬细胞和 Mon 衍生的巨噬细胞缺乏这种蛋白的表达。S100A9 依赖性巨噬细胞的免疫抑制活性涉及转录因子 C/EBPβ。肿瘤组织中存在 S100A9 阳性巨噬细胞与头颈部癌症患者的生存率较短以及转移性黑色素瘤患者对 PD-1 抗体治疗反应不佳相关。因此，这项研究揭示了免疫抑制性巨噬细胞的发展途径，并提出了一种针对它们的选择性靶向方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c02a/7809772/c336da9e64ef/nihms-1658645-f0007.jpg
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2
Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung.肺内髓系细胞多样性的转录组学和表观遗传学机制。
Nat Immunol. 2020 Feb;21(2):221-231. doi: 10.1038/s41590-019-0582-z. Epub 2020 Jan 20.
3
Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies.
Exploration of the Roles and Mechanisms Between Tumor-Infiltrating Lymphocytes and Hepatocellular Carcinoma Based on Single-Cell Transcriptomics.
基于单细胞转录组学探究肿瘤浸润淋巴细胞与肝细胞癌之间的作用及机制
Int J Genomics. 2025 Aug 20;2025:1575734. doi: 10.1155/ijog/1575734. eCollection 2025.
4
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.多组学分析在伴有KMT2A重排的谱系转换型急性髓系白血病中鉴定出一种类似M-MDSC的免疫抑制表型。
Nat Commun. 2025 Aug 26;16(1):7955. doi: 10.1038/s41467-025-63271-y.
5
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Cancer Immunol Immunother. 2025 Aug 6;74(9):281. doi: 10.1007/s00262-025-04137-6.
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