Babushkina T G, Bobryshev Iu V
Biull Eksp Biol Med. 1988 Jan;105(1):90-4.
Structural and functional characteristics of cells involved in collagen synthesis have been studied in experimental hypercholesterolemia in rabbits. Autoradiographic studies, using 3H-proline and 14C-hydroxyproline have demonstrated that collagen synthesis takes place only in the intima in the area of cellular proliferation. At earlier stages of experimental atherosclerosis collagen synthesis predominantly involves synthetic GABA phenotype, while at progressing stages fibroblasts are predominantly involved.
在兔实验性高胆固醇血症中，对参与胶原蛋白合成的细胞的结构和功能特征进行了研究。使用³H-脯氨酸和¹⁴C-羟脯氨酸的放射自显影研究表明，胶原蛋白合成仅发生在细胞增殖区域的内膜中。在实验性动脉粥样硬化的早期阶段，胶原蛋白合成主要涉及合成型GABA表型，而在进展阶段，主要涉及成纤维细胞。
