Nagornev V A, Babushkina T G
Biull Eksp Biol Med. 1987 Jan;103(1):104-6.
Aortic intima cell proliferation has been studied in 49 rabbits with progressing experimental hypercholesterolemia, using 3H-thymidine. It has been shown that focal cell proliferation is related to infiltration sites of apo-B lipoproteins and can be observed already at pre-lipid stage of atherogenesis. 4 types of proliferating cells involved in the formation of lipid plaques have been identified: endothelial cells, smooth muscle cells, fibroblasts and macrophages, with the latter predominating in the atherosclerotic plaque cover.
利用³H-胸腺嘧啶核苷，对49只患有进行性实验性高胆固醇血症的家兔的主动脉内膜细胞增殖情况进行了研究。结果表明，局灶性细胞增殖与载脂蛋白B脂蛋白的浸润部位有关，并且在动脉粥样硬化形成的脂质前期即可观察到。已鉴定出参与脂质斑块形成的4种增殖细胞类型：内皮细胞、平滑肌细胞、成纤维细胞和巨噬细胞，其中巨噬细胞在动脉粥样硬化斑块表层中占主导地位。
