Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2021 Jan;133:111040. doi: 10.1016/j.biopha.2020.111040. Epub 2020 Nov 28.
Myocardial Infarction Associated Transcript (MIAT) is a non-coding transcript which is located on chromosome 22q12.1. This lncRNA can regulate expression of genes at both transcriptional and post-transcriptional stages. It has been firstly recognized as a susceptibility locus for myocardial infarction. Subsequently, its role in the development of several human cancers has been acknowledged. Numerous researches have reported the impact of MIAT silencing on the reduction of cell viability, proliferation and invasion while enhancement of cellular senescence and apoptosis. Consistently, investigations in the xenograft models have verified MIAT role in the promotion of tumor growth. Numerous microRNAs such as miR-214, miR-22-3p, miR-520d-3p, miR-203a, miR-29a-3p, miR-141, miR-150, miR-302, miR-29, and miR-155-5p have functional interactions with this lncRNA. Moreover, dysregulation of MIAT has been associated with abnormal activity of numerous cancer-related signaling cascades such as Hippo, PI3K/Akt/c-Met and Wnt/β-catenin. In the current review, we explain the role of MIAT in the cancer evolution based on the outcomes of in vitro, in vivo and clinical studies.
心肌梗塞相关转录本（MIAT）是位于染色体 22q12.1 上的一种非编码转录本。这种长非编码 RNA 可以在转录和转录后水平调节基因的表达。它最初被认为是心肌梗塞的易感性位点。随后，其在几种人类癌症的发展中的作用得到了承认。大量研究报告了 MIAT 沉默对降低细胞活力、增殖和侵袭，同时增强细胞衰老和凋亡的影响。同样，在异种移植模型中的研究也验证了 MIAT 在促进肿瘤生长中的作用。许多 microRNAs 如 miR-214、miR-22-3p、miR-520d-3p、miR-203a、miR-29a-3p、miR-141、miR-150、miR-302、miR-29 和 miR-155-5p 与这种长非编码 RNA 具有功能相互作用。此外，MIAT 的失调与许多癌症相关信号通路的异常活动有关，如 Hippo、PI3K/Akt/c-Met 和 Wnt/β-catenin。在本综述中，我们根据体外、体内和临床研究的结果，解释了 MIAT 在癌症演变中的作用。
