SARS-CoV-2 对胃肠道和肝脏的潜在影响。

Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver.

机构信息

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China.

出版信息

Biomed Pharmacother. 2021 Jan;133:111064. doi: 10.1016/j.biopha.2020.111064. Epub 2020 Nov 28.

Abstract

COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.

摘要

新型冠状病毒肺炎(COVID-19)是由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的大流行疾病。早期报道的症状包括发热、咳嗽和呼吸道症状。有少数关于消化系统症状的报道。然而,随着 COVID-19 在全球范围内的传播,呕吐、腹泻和腹痛等症状引起了越来越多的关注。研究发现,血管紧张素转换酶 2(ACE2)是 SARS-CoV-2 的受体,在胃肠道和肝脏中强烈表达。无论是从理论上还是临床上,许多研究都表明 COVID-19 与消化系统密切相关。在这篇综述中,我们总结了现有研究中报道的消化系统症状,讨论了 SARS-CoV-2 对胃肠道和肝脏的影响,并确定了可能的机制和病因,如细胞因子风暴。深入探讨 COVID-19 与消化系统的关系是当务之急。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aabf/7700011/eebf4f7b750f/gr1_lrg.jpg

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