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Vimentin 在乳腺癌中的调控机制及临床意义。

Regulatory mechanisms and clinical significance of vimentin in breast cancer.

机构信息

Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China; West China College of Stomatology, Sichuan University, Chengdu, Sichuan Province, 610041, PR China.

Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China.

出版信息

Biomed Pharmacother. 2021 Jan;133:111068. doi: 10.1016/j.biopha.2020.111068. Epub 2020 Dec 8.

Abstract

Vimentin, a kind of intermediate filament protein III in mesenchymal cells, has become a highly researched topic around the world in recent years, as it holds complex biological functions and plays an important role in the epithelial-mesenchymal transition in the evolution of various tumors. This article reviews the biological function of vimentin and its relationship with breast cancer in order to provide novel ideas about the clinical diagnosis and targeted therapy of breast cancer.

摘要

波形蛋白是间充质细胞中的一种中间丝蛋白 III,近年来已成为全世界研究的热点,因为它具有复杂的生物学功能,并在各种肿瘤的上皮-间充质转化中发挥重要作用。本文综述了波形蛋白的生物学功能及其与乳腺癌的关系,以期为乳腺癌的临床诊断和靶向治疗提供新的思路。

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