通过癌症基因组图谱数据集探索波形蛋白在多种癌症类型中的表达及其蛋白质相互作用分子：一项综合分析。
Exploring vimentin expression and its protein interactors across diverse cancer types via the cancer genome atlas datasets: a comprehensive analysis.
作者信息
Blatkiewicz Małgorzata, Białas Piotr, Taryma-Leśniak Olga, Mazgaj Szymon, Hukowska-Szematowicz Beata, Jankowska Anna
机构信息
Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.
Chair and Department of Cell Biology, Poznan University of Medical Sciences, Poznań, Poland.
出版信息
Rep Pract Oncol Radiother. 2025 Mar 21;30(1):88-99. doi: 10.5603/rpor.104142. eCollection 2025.
BACKGROUND
The global burden of cancer is escalating, with millions of individuals diagnosed and succumbing to the disease each year. Early detection is crucial for improving patient outcomes, yet many cancers are identified at advanced stages. Vimentin (VIM) has emerged as a promising biomarker with significant diagnostic and prognostic potential.
MATERIALS AND METHODS
This study investigates expression and promoter methylation across various cancers using The Cancer Genome Atlas (TCGA) datasets. Additionally, we analyze protein-protein interactions and mutation frequencies using advanced bioinformatics tools.
RESULTS
Our findings reveal that is overexpressed in seven cancer types, including cholangiocarcinoma, glioblastoma multiforme, and breast invasive carcinoma. Notably, expression is correlated with promoter methylation in specific cancers. Furthermore, we identify complex protein interactions involving , highlighting its role in critical cellular processes such as proliferation and apoptosis.
CONCLUSION
These insights emphasize Vimentin's multifaceted role in cancer, suggesting its potential as both a therapeutic target and a diagnostic marker.
背景
癌症的全球负担正在不断升级，每年有数以百万计的人被诊断出患有癌症并因此死亡。早期检测对于改善患者预后至关重要，但许多癌症在晚期才被发现。波形蛋白（VIM）已成为一种具有显著诊断和预后潜力的有前景的生物标志物。
材料与方法
本研究使用癌症基因组图谱（TCGA）数据集调查了多种癌症中的波形蛋白表达和启动子甲基化情况。此外，我们使用先进的生物信息学工具分析了蛋白质-蛋白质相互作用和突变频率。
结果
我们的研究结果显示，波形蛋白在包括胆管癌、多形性胶质母细胞瘤和乳腺浸润性癌在内的七种癌症类型中过表达。值得注意的是，波形蛋白的表达与特定癌症中的启动子甲基化相关。此外，我们确定了涉及波形蛋白的复杂蛋白质相互作用，突出了其在增殖和凋亡等关键细胞过程中的作用。
结论
这些见解强调了波形蛋白在癌症中的多方面作用，表明其作为治疗靶点和诊断标志物的潜力。
Zotero 插件