Karolinska Radiopharmacy, Karolinska University Hospital, Akademiska stråket 1, S-171 64, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Akademiska stråket 1, S-171 77, Stockholm, Sweden.
Talanta. 2021 Mar 1;224:121794. doi: 10.1016/j.talanta.2020.121794. Epub 2020 Oct 27.
Since chiral recognition mechanism based on molecularly imprinted polymers immerged, it has assisted countless chemical and electrochemical analytical sample preparation techniques. It has done this by enhancing the enatioseparation abilities of these techniques. The preparation and optimization of chiral molecularly imprinted polymers (CMIPs) are two favored methods in the separation and sensor fields. This review aims to present an overview of advances in the preparation and application of CMIPs in analytical approaches in different available formats (eg. column, monolithic column, cartridge, membrane, nanomaterials, pipette tip and stir bar sorptive) over the last decade. In addition, progress in the preparation and development of CMIPs-based sensor fields have been also discussed. Finally, the main application challenges of CMIPs are also summarily explained, as well as upcoming prospects in the field.
自基于分子印迹聚合物的手性识别机制出现以来，它已经辅助了无数的化学和电化学分析样品制备技术。它通过增强这些技术的对映体分离能力做到了这一点。手性分子印迹聚合物（CMIPs）的制备和优化是分离和传感器领域中两种受欢迎的方法。本综述旨在概述过去十年中 CMIPs 在不同可用形式（例如，柱、整体柱、筒、膜、纳米材料、移液管尖端和搅拌棒吸附）的分析方法中的制备和应用方面的进展。此外，还讨论了基于 CMIPs 的传感器领域的制备和发展进展。最后，还简要说明了 CMIPs 的主要应用挑战以及该领域未来的发展前景。
