Rosenmund A, Köchli H P, König M P
Department of Medicine, University of Berne, Inselspital, Switzerland.
Blut. 1988 Jan;56(1):13-7. doi: 10.1007/BF00321054.
Hematological data known or supposed to be influenced by individual sex hormones were evaluated in 18 untreated transsexuals (TS) and in 20 castrated or non-castrated TS on androgen and estrogen treatment, respectively. Profiting from a situation of clinically controlled hormonal sex-transformation it was tested, whether the circulating erythrocyte and granulocyte mass and iron metabolism are linked to a male and female sex-hormone constellation. The erythrocyte and granulocyte counts were significantly higher in untreated males and treated female-to-male TS than in untreated females and treated male-to-female TS. The unexpected finding of sex hormone-dependent granulocyte fluctuations was corroborated by parallel concentration changes of lactoferrin, a granulocyte-derived plasma protein. Iron metabolism as judged from plasma iron, total iron-binding capacity and serum ferritin was unaffected by sexual transformation. Plasma iron and the total iron-binding capacity did not differ significantly in untreated and treated TS of either type. The serum ferritin concentration, however, was significantly lower in untreated as well as in virilized females than in untreated and in feminized males, but was not significantly changed by long-term androgen or estrogen treatment. The present study demonstrates the potential of human transsexualism as a model for the study of sex-related biological processes.
对18名未经治疗的变性者（TS）以及分别接受雄激素和雌激素治疗的20名去势或未去势的变性者中已知或推测受个体性激素影响的血液学数据进行了评估。利用临床可控的激素性别转换情况，测试循环红细胞和粒细胞量以及铁代谢是否与男性和女性性激素组合相关。未经治疗的男性和接受治疗的女性向男性转变的TS中的红细胞和粒细胞计数显著高于未经治疗的女性和接受治疗的男性向女性转变的TS。乳铁蛋白（一种粒细胞衍生的血浆蛋白）的平行浓度变化证实了性激素依赖性粒细胞波动这一意外发现。从血浆铁、总铁结合能力和血清铁蛋白判断，铁代谢不受性别转换的影响。无论是哪种类型的未经治疗和接受治疗的TS，血浆铁和总铁结合能力均无显著差异。然而，未经治疗的女性以及男性化女性的血清铁蛋白浓度显著低于未经治疗的男性以及女性化男性，但长期雄激素或雌激素治疗并未使其发生显著变化。本研究证明了人类易性癖作为研究性别相关生物学过程模型的潜力。
