Romslo I, Haram K, Sagen N, Augensen K
Br J Obstet Gynaecol. 1983 Feb;90(2):101-7. doi: 10.1111/j.1471-0528.1983.tb08891.x.
Serum iron, serum iron-binding capacity, serum ferritin and erythrocyte protoporphyrin were determined during uncomplicated pregnancy in 45 healthy women; 22 were given oral iron while the others were given a placebo. When iron was not given, 15 out of 23 women had exhausted iron stores and iron deficiency at term, as judged from low serum ferritin, low serum transferrin saturation and high erythrocyte protoporphyrin values. Only seven of them had a haemoglobin concentration between 10 and 11 g/dl at term but none had values less than 10 g/dl. In the iron-treated group (n = 22) none of the women developed iron deficiency. Serum ferritin was the most sensitive and specific test of iron deficiency. A practical procedure to detect iron deficiency and to control iron supplementation in pregnancy is suggested.
对45名健康女性在无并发症妊娠期间测定了血清铁、血清铁结合能力、血清铁蛋白和红细胞原卟啉；22名女性口服铁剂，其余女性服用安慰剂。未补充铁剂时，根据血清铁蛋白水平低、血清转铁蛋白饱和度低和红细胞原卟啉值高判断，23名女性中有15名在足月时铁储备耗尽且缺铁。其中只有7名女性足月时血红蛋白浓度在10至11g/dl之间，但没有一名女性的值低于10g/dl。在铁剂治疗组（n = 22）中，没有女性出现缺铁情况。血清铁蛋白是缺铁最敏感和特异的检测指标。本文提出了一种在孕期检测缺铁和控制铁剂补充的实用方法。
