Opt Express. 2020 Dec 21;28(26):39904-39915. doi: 10.1364/OE.413230.
Optical diffraction tomography (ODT) is used to reconstruct refractive-index distributions from multiple measurements in the object rotating configuration (ORC) or the illumination scanning configuration (ISC). Because of its fast data acquisition and stability, ISC-based ODT has been widely used for biological imaging. ODT typically fails to reconstruct multiply-scattering samples. The previously developed iterative ODT (iODT) was for the multiply-scattering objects in ORC, and could not be directly applied to ISC. To resolve this mismatch, we developed an ISC update and numerically demonstrated its accuracy. With the same prior knowledge, iODT-ISC outperforms conventional ODT in resolving the missing-angle problem.
光学衍射层析成像（ODT）用于从物体旋转配置（ORC）或照明扫描配置（ISC）中的多个测量值重建折射率分布。由于其快速的数据采集和稳定性，基于 ISC 的 ODT 已被广泛用于生物成像。ODT 通常无法重建多次散射样本。先前开发的迭代 ODT（iODT）是针对 ORC 中的多次散射物体的，不能直接应用于 ISC。为了解决这个不匹配的问题，我们开发了一种 ISC 更新，并对其准确性进行了数值验证。在相同的先验知识下，iODT-ISC 在解决缺失角问题方面优于传统的 ODT。
