Suppr超能文献

[通过视频胶囊内镜诊断的乳糜泻患者小肠腺癌:病例报告及文献复习]

[Small bowel adenocarcinoma diagnosed by video capsule endoscopy in a patient with celiac disease: a case report and review of literature].

作者信息

Packová Barbora, Kunovský Lumír, Eid Michal, Kroupa Radek, Dastych Milan, Šenkyřík Michal, Grolich Tomáš, Hustý Jakub, Jabandžiev Petr, Kubeš Václav, Prochazka Vladimír, Dolina Jiří

出版信息

Vnitr Lek. 2020 Fall;66(7):39-42.

Abstract

Celiac disease is an immune mediated entheropathy triggered by gluten in genetically predisposed individuals. Patients with celiac disease are at a higher risk of gastrointestinal malignancies. Diagnosis at an advance stage is one of the factors of an unfavorable prognosis of these complications. Our patient is a woman who was diagnosed with celiac disease at 53 years of age. After two years on a gluten-free diet she developed sideropenic anemia. No source of bleeding was found on the esophagogastroduodenoscopy or colonoscopy. Video capsule endoscopy revealed exulcerated bleeding stenosis in the jejunum, in front of which the capsule lodged. There were no signs of infiltration on simultaneous CT enterography. The patient was operated on and the infiltration of the jejunum was resected. The specimen was evaluated by a histopathologist as a moderately differentiated adenocarcinoma. Due to the risk factors, the patient received adjuvant chemotherapy. The knowledge of the malignant complications of celiac disease, their risk factors and the possibilities of modern enteroscopic methods could help in the early diagnosis and improvement of the prognosis of these diseases. Due to a lack of data and an absence of guidelines, treatment of a small bowel adenocarcinoma is based on an expert agreement and guidelines for colon cancer. Surgical treatment is the only potentially curative option. For stage II with risk factors and stage III adjuvant chemotherapy should be considered.

摘要

乳糜泻是一种由麸质引发的免疫介导性肠病,发生于具有遗传易感性的个体。乳糜泻患者患胃肠道恶性肿瘤的风险更高。晚期诊断是这些并发症预后不良的因素之一。我们的患者是一名53岁被诊断为乳糜泻的女性。在无麸质饮食两年后,她出现了缺铁性贫血。在食管胃十二指肠镜检查或结肠镜检查中未发现出血源。视频胶囊内镜检查显示空肠有溃疡出血性狭窄,胶囊停留在其前方。同时进行的CT小肠造影未发现浸润迹象。患者接受了手术,切除了空肠浸润部分。病理学家将标本评估为中分化腺癌。由于存在风险因素,患者接受了辅助化疗。了解乳糜泻的恶性并发症、其风险因素以及现代小肠镜检查方法的可能性有助于早期诊断并改善这些疾病的预后。由于缺乏数据且没有指南,小肠腺癌的治疗基于专家共识和结肠癌指南。手术治疗是唯一可能治愈的选择。对于有风险因素的II期和III期患者,应考虑辅助化疗。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验