Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Assistive Technology Centre, Central Finland Health Care District, Jyväskylä, Finland.
Nord J Psychiatry. 2021 Jul;75(5):356-361. doi: 10.1080/08039488.2020.1862296. Epub 2020 Dec 30.
The aims of this study were to investigate whether baseline leisure-time physical activity (LTPA) is associated with future recovery from depression among patients with a depression diagnosis and whether baseline LTPA is associated with total physical activity after five years of follow-up.
A total of 258 patients aged ≥35 years with clinically confirmed depression at baseline participated. The study was conducted between 2008 and 2016 in municipalities within the Central Finland Hospital District. Depressive symptoms (DS) were determined with the Beck Depression Inventory (BDI) with a cutoff score ≥10, and depression diagnoses were confirmed by the Mini-International Neuropsychiatric Interview (MINI). Blood pressure and anthropometric parameters were measured and blood samples for glucose and lipid determinations were drawn at baseline. LTPA, physical activity, and other social and clinical factors were captured by standard self-administered questionnaires at baseline and the five-year follow-up point.
Of the 258 patients, 76 (29%) had DS at follow-up. Adjusted odds ratio (OR) for future DS was 1.43 (confidence interval [CI] 0.69-2.95) for participants with moderate LTPA and 0.92 (CI 0.42-2.00) for participants with high LTPA, compared with low LTPA at baseline. Higher baseline LTPA levels were associated with higher total physical activity in the future (0.14 [95% CI: 0.02-0.26] for linearity = 0.024).
Baseline LTPA did not affect the five-year prognosis of depression among depressed patients in a Finnish adult population. Because the baseline LTPA level predicted the future total physical activity, it could be included as a part of the overall health management and treatment of depression in clinical practices.
本研究旨在探讨基线休闲时间体力活动（LTPA）是否与确诊抑郁症患者未来的抑郁恢复有关，以及基线 LTPA 是否与五年随访后的总体力活动有关。
共有 258 名年龄≥35 岁的患者在基线时患有经临床确诊的抑郁症，本研究于 2008 年至 2016 年在芬兰中芬兰区的市级行政区进行。采用贝克抑郁量表（BDI）评估抑郁症状，截断值≥10 分，使用迷你国际神经精神访谈（MINI）确认抑郁症诊断。在基线时测量血压和人体测量参数，并采集血液样本以测定血糖和血脂。通过标准的自我管理问卷在基线和五年随访点收集 LTPA、体力活动和其他社会及临床因素的数据。
在 258 名患者中，76 名（29%）在随访时出现了抑郁症状。与基线时低水平 LTPA 相比，中等水平 LTPA 患者未来出现抑郁症状的调整后比值比（OR）为 1.43（95%置信区间 [CI] 0.69-2.95），高水平 LTPA 患者为 0.92（CI 0.42-2.00）。较高的基线 LTPA 水平与未来更高的总体力活动相关（线性趋势=0.024，P=0.024），差值为 0.14（95%CI：0.02-0.26）。
在芬兰成年人群中，基线 LTPA 并不影响抑郁患者五年的抑郁预后。由于基线 LTPA 水平可预测未来的总体力活动，因此它可以作为整体健康管理的一部分，纳入临床实践中的抑郁症治疗中。
