Department of Radiotherapy, Kurnool Medical College, Affiliated to Dr. NTR University of Health Sciences, Kurnool, Andhra Pradesh, India.
Department of Radiotherapy, Siddhartha Medical College, Affiliated to Dr. NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India.
J Cancer Res Ther. 2020 Dec;16(Supplement):S172-S175. doi: 10.4103/jcrt.JCRT_912_17.
Colorectal cancer is relatively uncommon malignancy in India when compared with the Western world, disease affecting individuals above 40 years of age and is rare below 40 years of age. However, now there is an increase in young age presentation globally and India.
We conducted a retrospective study of all colorectal carcinomas colorectal cancer (CRC) that were diagnosed during the past 6 years, i.e., from January 2011 to December 2016. Patients were divided into two groups - below 40 years and above 40 years. The records were analyzed in detail for age, gender, site of primary tumor, and histopathological type. The results of the two groups were compared and in turn compared with population-based cancer registry (PBCR) of Delhi, Mumbai, Kolkata, Chennai, and Bengaluru.
Two hundred and twenty-three patients were diagnosed to have CRC. Patients diagnosed below 40 years of age comprised 39.5% (88) compared with PBCR of Delhi (19.75%, P value significant at <0.05), Mumbai (10.9%), P value significant at <0.05), Kolkata (13.1%, P value significant at <0.05), Chennai (8.6%, P value significant at <0.05), and Bengaluru (13.6%, P value significant at <0.05). Among patients below 40 years of age, majority were males (56.8%), most occurred in the rectum (75%). Poorly differentiated, mucin-secreting, signet ring type adenocarcinomas are most frequent (35.2%) and presented at advanced stage (33%). This was similar to those reported in other literatures.
Study shows that there is a rise in younger age presentation in our institution with rectal site predominance, advanced stage, and poor histopathological variants.
与西方世界相比，印度的结直肠癌发病率相对较低，主要影响 40 岁以上人群，40 岁以下人群较为罕见。然而，现在全球范围内年轻人的发病率都在增加，包括印度。
我们对过去 6 年内（即 2011 年 1 月至 2016 年 12 月）诊断的所有结直肠癌患者进行了回顾性研究。患者分为 40 岁以下和 40 岁以上两组。详细分析了年龄、性别、原发肿瘤部位和组织病理学类型等记录。比较两组结果，并与德里、孟买、加尔各答、钦奈和班加罗尔的人群癌症登记处（PBCR）进行了比较。
共诊断出 223 例结直肠癌患者。40 岁以下患者占 39.5%（88 例），与德里的 PBCR（19.75%，P 值显著<0.05）、孟买（10.9%，P 值显著<0.05）、加尔各答（13.1%，P 值显著<0.05）、钦奈（8.6%，P 值显著<0.05）和班加罗尔（13.6%，P 值显著<0.05）相比，差异有统计学意义。在 40 岁以下的患者中，男性居多（56.8%），多数发生在直肠（75%）。低分化、分泌黏液、印戒细胞型腺癌最常见（35.2%），且处于晚期（33%）。这与其他文献报道的结果相似。
研究表明，我们机构的年轻患者就诊率呈上升趋势，以直肠部位为主，分期较晚，组织病理学类型较差。
