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抗肿瘤治疗前的血清钙水平可预测鼻咽癌患者的临床结局。

Serum Calcium Levels Before Antitumour Therapy Predict Clinical Outcomes in Patients with Nasopharyngeal Carcinoma.

作者信息

Huang Sheng-Yan, Chen Yang, Tan Xi-Rong, Gong Sha, Yang Xiao-Jing, He Qing-Mei, He Shi-Wei, Liu Na, Li Ying-Qing

机构信息

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Dec 23;13:13111-13119. doi: 10.2147/OTT.S275613. eCollection 2020.

DOI:10.2147/OTT.S275613
PMID:33380801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7767708/
Abstract

PURPOSE

The prognostic value of serum calcium levels in nasopharyngeal carcinoma (NPC) remains unknown. This study aimed to evaluate the prognostic value of serum calcium levels in patients with NPC.

PATIENTS AND METHODS

A total of 2094 patients diagnosed with NPC between April 2009 and September 2012 were enrolled in this retrospective analysis. The median follow-up time was 96.3 months (range: 4.1-120.0 months). Univariate and multivariable Cox proportional hazards models were used to identify significant and independent prognostic predictors of overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and relapse-free survival (RFS).

RESULTS

Overall, low serum calcium levels were detected in 1109/2094 (53.00%) patients and tended to be more frequently detected in older (<0.001) and female (=0.001) patients. Patients with low serum calcium levels had poorer OS (=0.011), DFS (=0.012) and DMFS (=0.004) than those with high serum calcium levels, but serum calcium levels had no significant effect on RFS (=0.376). In univariate and multivariable analyses, low serum calcium levels were a statistically significant and independent prognostic factor for OS, DFS, and DMFS but had no prognostic value for RFS.

CONCLUSION

Serum calcium levels can serve as a prognostic predictor and guide more individualized treatment for NPC patients.

摘要

目的

血清钙水平在鼻咽癌（NPC）中的预后价值尚不清楚。本研究旨在评估血清钙水平在鼻咽癌患者中的预后价值。

患者与方法

本回顾性分析纳入了2009年4月至2012年9月期间诊断为NPC的2094例患者。中位随访时间为96.3个月（范围：4.1 - 120.0个月）。采用单因素和多因素Cox比例风险模型来确定总生存期（OS）、无病生存期（DFS）、无远处转移生存期（DMFS）和无复发生存期（RFS）的显著和独立预后预测因素。

结果

总体而言，1109/2094（53.00%）例患者检测到低血清钙水平，且在老年患者（<0.001）和女性患者（=0.001）中更常检测到。血清钙水平低的患者的OS（=0.011）、DFS（=0.012）和DMFS（=0.004）均比血清钙水平高的患者差，但血清钙水平对RFS无显著影响（=0.376）。在单因素和多因素分析中，低血清钙水平是OS、DFS和DMFS的统计学显著且独立的预后因素，但对RFS无预后价值。

结论

血清钙水平可作为NPC患者的预后预测指标，并指导更个体化的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bba/7767708/c16531b39124/OTT-13-13111-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bba/7767708/c16531b39124/OTT-13-13111-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bba/7767708/c16531b39124/OTT-13-13111-g0001.jpg

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