Mainard F, Madec Y, Robinet N
Laboratoire de Biochimie Pharmaceutique, UER des Sciences Pharmaceutiques, Nantes, France.
Clin Chem. 1988 Jan;34(1):139-40.
We analyzed correlations between apolipoprotein B (apo B), cholesterol and phospholipids (preponderant lipids) in low-density lipoproteins (LDL) as well as between apolipoprotein A1 (apo A1) and these same lipids in high-density lipoproteins (HDL), during the acute phase of myocardial infarction. In LDL, a very elevated and stable correlation (r) was observed between these parameters, and the coefficients of regression (b) did not differ significantly during the period studied. In HDL, there was a decrease in r and b values from day 1 to day 2, then an increase after day 2. We hypothesize that these disturbances in HDL composition may be due to a greater endocytosis of LDL at day 2, leading to intracellular increase in cholesterol and phospholipids. Part of these lipids could be taken up by HDL molecules, causing a transient overload.
我们分析了心肌梗死急性期低密度脂蛋白（LDL）中载脂蛋白B（apo B）、胆固醇和磷脂（主要脂质）之间的相关性，以及高密度脂蛋白（HDL）中载脂蛋白A1（apo A1）与这些相同脂质之间的相关性。在LDL中，这些参数之间观察到非常高且稳定的相关性（r），并且在所研究的期间内回归系数（b）没有显著差异。在HDL中，从第1天到第2天r和b值下降，然后在第2天后上升。我们推测HDL组成的这些紊乱可能是由于第2天LDL的内吞作用增强，导致细胞内胆固醇和磷脂增加。这些脂质的一部分可能被HDL分子摄取，导致短暂的过载。
