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电压门控钾通道作为细胞死亡的调节因子

Voltage-Gated Potassium Channels as Regulators of Cell Death.

作者信息

Bachmann Magdalena, Li Weiwei, Edwards Michael J, Ahmad Syed A, Patel Sameer, Szabo Ildiko, Gulbins Erich

机构信息

Department of Biology, University of Padova, Padua, Italy.

Department of Surgery, Medical School, University of Cincinnati, Cincinnati, OH, United States.

出版信息

Front Cell Dev Biol. 2020 Dec 14;8:611853. doi: 10.3389/fcell.2020.611853. eCollection 2020.

DOI:10.3389/fcell.2020.611853
PMID:33381507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7767978/
Abstract

Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume regulation and to the physiologically relevant modulation of intracellular potassium concentration. In turn, these factors affect cell cycle progression, proliferation and apoptosis. The present review summarizes our current knowledge about the involvement of various voltage-gated channels of the Kv family in the above processes and discusses the possibility of their pharmacological targeting in the context of cancer with special emphasis on Kv1.1, Kv1.3, Kv1.5, Kv2.1, Kv10.1, and Kv11.1.

摘要

离子通道允许特定离子跨生物膜流动，从而决定细胞内的离子稳态。电压门控钾选择性离子通道对质膜电位的设定、体积调节以及细胞内钾浓度的生理相关调节起着关键作用。反过来，这些因素会影响细胞周期进程、增殖和凋亡。本综述总结了我们目前关于Kv家族各种电压门控通道参与上述过程的知识，并讨论了在癌症背景下对其进行药物靶向治疗的可能性，特别强调了Kv1.1、Kv1.3、Kv1.5、Kv2.1、Kv10.1和Kv11.1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/dbacfe4bee47/fcell-08-611853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/baab303088cf/fcell-08-611853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/b71c87dff4f1/fcell-08-611853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/9a68f1eeb355/fcell-08-611853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/85c84527f6a7/fcell-08-611853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/dbacfe4bee47/fcell-08-611853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/baab303088cf/fcell-08-611853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/b71c87dff4f1/fcell-08-611853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/9a68f1eeb355/fcell-08-611853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/85c84527f6a7/fcell-08-611853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e69/7767978/dbacfe4bee47/fcell-08-611853-g005.jpg

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