Sinha Sukesh Narayan, Ramakrishna Ungarala Venkat, Sinha P K, Thakur C P
Food Safety Division, National Institute of Nutrition, Hyderabad, Telangana, India.
RMRI, Patna, India.
PLoS One. 2020 Dec 31;15(12):e0244798. doi: 10.1371/journal.pone.0244798. eCollection 2020.
Litchi fruits are a nutritious and commercial crop in the Indian state of Bihar. Litchi fruit contains a toxin, methylene cyclopropyl-glycine (MCPG), which is known to be fatal by causing encephalitis-related deaths. This is especially harmful when consumed by malnourished children. The first case of litchi toxicity was reported in Bihar in 2011. A similar event was recorded in 2014 among children admitted to the Muzaffarpur government hospital, Bihar. Litchi samples sent to ICMR-NIN were analyzed and MCPG was found to be present in both the pulp and seed of the fruit. Diethyl phosphate (DEP) metabolites were found in the urine samples of children who had consumed litchi fruit from this area indicating exposure to pesticide. The presence of both MCPG in litchi and DEP metabolites in urine samples highlights the need to conduct a comprehensive investigation that examines all factors of toxicity.
荔枝是印度比哈尔邦一种营养丰富的经济作物。荔枝果实含有一种毒素，即亚甲基环丙基甘氨酸（MCPG），已知该毒素会导致与脑炎相关的死亡，具有致命性。对于营养不良的儿童来说，食用荔枝尤其有害。2011年，比哈尔邦首次报告了荔枝中毒事件。2014年，在比哈尔邦穆扎法尔布尔政府医院收治的儿童中也记录到了类似事件。送往印度医学研究理事会-国家营养研究所（ICMR-NIN）的荔枝样本经过分析，发现果实的果肉和种子中均含有MCPG。在食用了该地区荔枝的儿童尿液样本中发现了磷酸二乙酯（DEP）代谢物，表明他们接触了农药。荔枝中MCPG的存在以及尿液样本中DEP代谢物的存在凸显了开展全面调查以研究所有毒性因素的必要性。
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