血清髓系细胞相关蛋白 8/14 是糖尿病肾病的潜在预测指标。

Serum myeloid-related protein 8/14 is a potential predictor of diabetic kidney disease.

机构信息

Departments of Endocrinology and ICU, the Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.

Weifang University Science and Technology, Shouguang, Shandong 262700, China.

出版信息

Discov Med. 2020 Sep-Oct;30(160):97-105.

PMID:33382965

Abstract

BACKGROUND

Myeloid-related protein 8/14 (MRP8/14) is secreted by macrophages and formed by MRP8 and MRP14, which is closely related to vascular inflammation. Chronic vascular inflammation plays a significant role in the development and progression of diabetic kidney disease (DKD). This study aims to investigate the relationship between MRP8/14 and DKD.

METHODS

A total of 80 individuals with type 2 diabetes were divided into four groups, according to the baseline urinary albumin/creatinine ratio (ACR) levels Serum concentrations of MRP8/14 were measured by ELISA. The clinical variables were obtained through physical examination, illness history, or laboratory evidence.

RESULTS

As DKD worsened, the level of serum MRP8/14 increased gradually, and MRP8/14 has a significantly positive correlation with ACR (r = 0.349, P = 0.002), body mass index (BMI) (r = 0.288, P = 0.009), serum creatinine (Cre) (r = 0.392, P < 0.001), blood urine nitrogen (BUN) (r = 0.333, P = 0.003), systolic blood pressure (SBP) (r = 0.301, P = 0.007), and a negative correlation with the estimated glomerular filtration rate (eGFR) (r = -0.478, P < 0.001). Logistic regression analysis showed that age, Cre, eGFR, ACR, and MRP8/14 were associated with the progression of DKD (P < 0.05).

CONCLUSIONS

The serum MRP8/14 is correlated significantly with the progression of DKD, suggesting that MRP8/14 may be an independent predictor of the progression of DKD.

摘要

背景

髓系细胞相关蛋白 8/14（MRP8/14）由巨噬细胞分泌，由 MRP8 和 MRP14 组成，与血管炎症密切相关。慢性血管炎症在糖尿病肾病（DKD）的发生和发展中起重要作用。本研究旨在探讨 MRP8/14 与 DKD 的关系。

方法

共纳入 80 例 2 型糖尿病患者，根据基线尿白蛋白/肌酐比值（ACR）水平将其分为 4 组，采用酶联免疫吸附试验（ELISA）法检测血清 MRP8/14 浓度。通过体格检查、病史或实验室证据获得临床变量。

结果

随着 DKD 的恶化，血清 MRP8/14 水平逐渐升高，且 MRP8/14 与 ACR 呈显著正相关（r=0.349，P=0.002），与体质量指数（BMI）（r=0.288，P=0.009）、血清肌酐（Cre）（r=0.392，P<0.001）、血尿素氮（BUN）（r=0.333，P=0.003）呈正相关，与估计肾小球滤过率（eGFR）呈负相关（r=-0.478，P<0.001）。Logistic 回归分析显示，年龄、Cre、eGFR、ACR 和 MRP8/14 与 DKD 的进展有关（P<0.05）。