Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Cardiovasc Diabetol. 2011 May 18;10:41. doi: 10.1186/1475-2840-10-41.
Myeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8/14, hsCRP, endogenous secretory receptor for advanced glycation end-products (esRAGE) and the occurrence of coronary artery disease (CAD), or carotid intima-media thickness (IMT) when CAD was not yet developed in diabetic patients.
Serum levels of MRP8/14, esRAGE and hsCRP were measured in 375 diabetic patients. Then the results of those who had CAD were compared against who had not. Also, we investigated the associations between above-mentioned indicators and IMT of subjects without CAD in both diabetic group and non-diabetic one.
Serum MRP8/14 was significantly higher in CAD than in non-CAD group (9.7 ± 3.6 ug/ml vs. 8.2 ± 3.0 ug/ml, P < 0.001). It was associated with severity of CAD (r = 0.16, P = 0.026). In non-CAD group, MRP8/14 was associated with IMT in patients with (r = 0.30, P < 0.001) or without diabetes (r = 0.26, P = 0.015). The areas under the curves of receiver operating characteristic for CAD were 0.63 (95% CI 0.57-0.68) for MRP8/14, 0.76 (95% CI 0.71-0.81) for hsCRP and 0.62 (95% CI 0.56 -0.67) for esRAGE.
In summary, we report that diabetic patients with CAD had elevated plasma MRP8/14 levels which were also positively correlated with the severity of CAD and carotid IMT in patients without clinically overt CAD.
髓样细胞相关蛋白 8/14（MRP8/14）是由两种不同的钙结合蛋白（MRP8 和 MRP14）形成的稳定异二聚体。研究表明，MRP8/14 调节血管炎症，是急性冠状动脉综合征的新型标志物。在本研究中，我们评估了血清 MRP8/14、hsCRP、晚期糖基化终产物内源性分泌受体（esRAGE）水平与未发生急性冠状动脉综合征（CAD）的糖尿病患者的 CAD 发生以及颈动脉内膜中层厚度（IMT）之间的相关性。
检测 375 例糖尿病患者的血清 MRP8/14、esRAGE 和 hsCRP 水平，然后将发生 CAD 的患者与未发生 CAD 的患者进行比较。此外，我们还在糖尿病组和非糖尿病组中，调查了上述指标与无 CAD 患者 IMT 之间的相关性。
CAD 组血清 MRP8/14 显著高于非 CAD 组（9.7±3.6μg/ml 比 8.2±3.0μg/ml，P＜0.001）。MRP8/14 与 CAD 的严重程度相关（r=0.16，P=0.026）。在非 CAD 组中，MRP8/14 与伴有（r=0.30，P＜0.001）或不伴有糖尿病（r=0.26，P=0.015）的患者的 IMT 相关。MRP8/14 对 CAD 的曲线下面积为 0.63（95%CI 0.57-0.68），hsCRP 为 0.76（95%CI 0.71-0.81），esRAGE 为 0.62（95%CI 0.56-0.67）。
综上所述，我们报道糖尿病合并 CAD 患者的血浆 MRP8/14 水平升高，且与无临床明显 CAD 患者的 CAD 严重程度和颈动脉 IMT 呈正相关。
