Periodontology, Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK.
Research & Development, The Procter & Gamble Company, Mason, OH, 45040, USA.
J Dent. 2021 Feb;105:103566. doi: 10.1016/j.jdent.2020.103566. Epub 2020 Dec 28.
To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion.
A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials.
Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF toothpastes provided a 57 % (evaporative air) and 142 % (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p < 0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22 % advantage (p = 0.036) was seen for evaporative air. In erosion studies, SnF toothpastes provided an 83 % benefit versus control toothpastes (arginine or sodium fluoride; p < 0.001) with a change (95 %CI) in average surface profilometry level (μm) of -2.02(-2.85, -1.20).
The use of these bioavailable SnF toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
比较生物可利用的葡萄糖酸-螯合氟化亚锡（SnF）牙膏与对照牙膏在治疗牙本质敏感（DH）和牙釉质腐蚀方面的效果。
审查了宝洁口腔护理 2000 年至 2020 年的临床研究档案。合格的研究是随机对照试验（RCT），研究了生物可利用的葡萄糖酸-螯合 SnF 牙膏在成人参与者中的功效，这些参与者在体内使用触觉（Yeaple 力）和/或蒸发刺激（ Schiff 评分）进行测量，持续时间<2 个月（DH）；或通过原位样本的侵蚀性牙磨损（轮廓测量）进行测量，持续时间为 10-15 天。两名作者独立评估合格性，并通过讨论解决分歧。进行了荟萃分析，并使用 Cochrane 协作对随机平行组和交叉试验的 RoB 工具评估了 RoB（风险偏倚）。
14 项 RCT（1287 名参与者）评估了 DH 缓解，6 项 RCT（184 名参与者）评估了牙釉质腐蚀保护。对于 DH，SnF 牙膏相对于阴性对照（氟化钠/单氟磷酸钠，8 项研究；p<0.001）提供了 57%（蒸发空气）和 142%（触觉）的益处。与阳性对照（硝酸钾或精氨酸，6 项研究）相比，蒸发空气方面有 22%的优势（p=0.036）。在侵蚀研究中，SnF 牙膏相对于对照牙膏（精氨酸或氟化钠；p<0.001）具有 83%的益处，平均表面轮廓测量水平（μm）的变化（95%CI）为-2.02（-2.85，-1.20）。
作为日常口腔卫生方案的一部分，使用这些生物可利用的 SnF 牙膏将为患者提供牙釉质腐蚀保护，同时缓解现有 DH 疼痛，提高生活质量。
