Novozhilova Nina, Andreeva Elena, Polyakova Maria, Makeeva Irina, Sokhova Inna, Doroshina Vladlena, Zaytsev Alexandr, Babina Ksenia
Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Institute of Linguistics and Intercultural Communication, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Dent J (Basel). 2023 Apr 4;11(4):96. doi: 10.3390/dj11040096.
Gingivitis is a widespread disease commonly associated with dentin hypersensitivity, that, in turn, may complicate routine dental care, leading to plaque accumulation. We aimed to assess the antigingivitis, desensitizing, and antiplaque effects of a fluoride-containing (TWF) alkaline toothpaste and a fluoride-free (TW) alkaline toothpaste. Eighty-four consenting patients aged 20-25 years with diagnosed gingivitis and dentin hypersensitivity (DH) were recruited in this double-blind, parallel-group study and randomly divided into two groups (each = 42). Eighty-two patients completed the entire study protocol. The outcomes were assessed after 4 weeks of intervention. A significant improvement in gingival condition was found according to the modified gingival index, with effect sizes of 0.99 [CI95%: 0.52-1.46] and 1.71 [CI95%: 1.18-2.24], and the gingival bleeding index, with effect sizes of 3.17 [CI95%: 2.39-3.94] and 2.64 [CI95%: 1.96-3.32] in the TW and TWF groups, respectively. DH also decreased in both groups, with a significantly greater reduction in the TWF group (effect sizes of 3.28 [CI95%: 2.51-4.04] and 3.10 [CI95%: 2.40-3.80] according to the visual analog scale and Schiff scale, respectively). No side effects were registered. In conclusion, the use of alkaline toothpaste provided a significant reduction in gingival inflammation and bleeding, DH, and oral hygiene after 4 weeks of daily use in young adults. Trial Registration: NCT0562376. Funding: none.
牙龈炎是一种常见疾病，通常与牙本质过敏相关，而牙本质过敏反过来又可能使常规牙科护理复杂化，导致牙菌斑积聚。我们旨在评估含氟（TWF）碱性牙膏和无氟（TW）碱性牙膏的抗牙龈炎、脱敏和抗牙菌斑效果。在这项双盲、平行组研究中，招募了84名年龄在20 - 25岁、诊断为牙龈炎和牙本质过敏（DH）的自愿参与患者，并随机分为两组（每组 = 42人）。82名患者完成了整个研究方案。干预4周后评估结果。根据改良牙龈指数，牙龈状况有显著改善，TW组和TWF组的效应大小分别为0.99 [CI95%: 0.52 - 1.46] 和1.71 [CI95%: 1.18 - 2.24]；根据牙龈出血指数，效应大小分别为3.17 [CI95%: 2.39 - 3.94] 和2.64 [CI95%: 1.96 - 3.32]。两组的牙本质过敏也有所降低，TWF组降低幅度显著更大（根据视觉模拟量表和希夫量表，效应大小分别为3.28 [CI95%: 2.51 - 4.04] 和3.10 [CI95%: 2.40 - 3.80]）。未记录到副作用。总之，在年轻成年人中，每天使用碱性牙膏4周后，牙龈炎症和出血、牙本质过敏以及口腔卫生状况均有显著改善。试验注册号：NCT0562376。资金来源：无。
