Department of Human Anatomy, Medical University of Lublin, 20-090 Lublin, Poland.
Department of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, Poland.
Int J Mol Sci. 2020 Dec 29;22(1):277. doi: 10.3390/ijms22010277.
Epithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the cellular phenotype into a malignant one. EMT has been shown to play a role in the malignant transformation and while occurring in the tumor microenvironment, it significantly affects the aggressiveness of gastric cancer, among others. Importantly, after EMT occurs, gastric cancer patients are more susceptible to the induction of resistance to various therapeutic agents, worsening the clinical outcome of patients. Therefore, there is an urgent need to search for the newest pharmacological agents targeting EMT to prevent further progression of gastric carcinogenesis and potential metastases. Therapies targeted at EMT might be combined with other currently available treatment modalities, which seems to be an effective strategy to treat gastric cancer patients. In this review, we have summarized recent advances in gastric cancer treatment in terms of targeting EMT specifically, such as the administration of polyphenols, resveratrol, tangeretin, luteolin, genistein, proton pump inhibitors, terpenes, other plant extracts, or inorganic compounds.
上皮-间充质转化（EMT）是癌症发生的标志之一，它包括上皮细胞重新分化为间充质细胞，将细胞表型改变为恶性表型。EMT 已被证明在恶性转化中起作用，并且在肿瘤微环境中发生时，它会显著影响胃癌等的侵袭性。重要的是，EMT 发生后，胃癌患者更容易对各种治疗药物产生耐药性，从而恶化患者的临床预后。因此，迫切需要寻找针对 EMT 的新型药理学制剂，以防止胃肿瘤发生和潜在转移的进一步进展。针对 EMT 的治疗方法可能与其他目前可用的治疗方式相结合，这似乎是治疗胃癌患者的有效策略。在这篇综述中，我们总结了针对 EMT 的胃癌治疗的最新进展，例如多酚、白藜芦醇、桔皮素、木樨草素、染料木黄酮、质子泵抑制剂、萜类化合物、其他植物提取物或无机化合物的应用。
