高硒暴露情况下人体谷胱甘肽过氧化物酶活性

Human glutathione peroxidase activity in cases of high selenium exposures.

作者信息

Valentine J L, Faraji B, Kang H K

机构信息

School of Public Health, Center for Health Sciences, University of California, Los Angeles 90024.

出版信息

Environ Res. 1988 Feb;45(1):16-27. doi: 10.1016/s0013-9351(88)80003-3.

DOI:10.1016/s0013-9351(88)80003-3

PMID:3338432

Abstract

Four communities with water supplies having selenium concentrations of less than 3.1, 1.7, 189, and 496 micrograms/liter were selected for study. Samples of blood, urine, and tap water were obtained from participants in each community and analyzed for selenium content. Blood samples were also analyzed for glutathione peroxidase activity. Results showed an increase in selenium concentration in the urine as the water selenium increased. Selenium concentrations in blood did not reflect the increased selenium exposure. Glutathione peroxidase activity in whole blood decreased in highly exposed participants compared to those with low exposure. We conclude that glutathione peroxidase activity in cases of possible environmental toxic exposures will not show the increased activity seen in supplementation of selenium to deficient subjects.

摘要

选择了四个社区进行研究，这些社区供水的硒浓度分别低于3.1、1.7、189和496微克/升。从每个社区的参与者那里采集了血液、尿液和自来水样本，并分析了其中的硒含量。还对血液样本进行了谷胱甘肽过氧化物酶活性分析。结果显示，随着水中硒含量的增加，尿液中的硒浓度升高。血液中的硒浓度并未反映出硒暴露的增加。与低暴露参与者相比，高暴露参与者全血中的谷胱甘肽过氧化物酶活性降低。我们得出结论，在可能存在环境毒性暴露的情况下，谷胱甘肽过氧化物酶活性不会表现出在给缺硒受试者补充硒时所看到的活性增加。