Shani J, Livshitz T, Robberecht H, Van Grieken R, Rubinstein N, Even-Paz Z
Pharmacol Res Commun. 1985 May;17(5):479-88. doi: 10.1016/0031-6989(85)90083-9.
Erythrocyte selenium-dependent glutathione peroxidase activity was measured in psoriatic Danes, before and after their four-week balneological therapy at the Ein-Bokek International Psoriasis Treatment Center, on the Dead-Sea shore in Israel. The drinking water in Ein-Bokek was found to be rich in selenium, a trace element with anticarcinogenic properties and of great importance in human nutrition and health. The most reliable biological parameter for increase in selenium bioavailability is the erythrocytes' glutathione-peroxidase activity. As psoriasis is a proliferative skin disease, the activity of this enzyme was assayed in 35 psoriatic Danes and in 25 long-term local hotel workers, as well as in 34 volunteers drinking low-selenium water. The glutathione peroxidase activity in the psoriatic patients increased significantly during their four-week stay in Ein-Bokek. Erythrocyte glutathione peroxidase activity in the hotel workers was 50% higher than that in the healthy volunteers consuming low-selenium water. A possible role of selenium in psoriasis is suggested.
在以色列死海之滨的艾因-布凯克国际银屑病治疗中心，对患有银屑病的丹麦人进行了为期四周的温泉疗法，在此前后测定了他们红细胞中硒依赖性谷胱甘肽过氧化物酶的活性。发现艾因-布凯克的饮用水富含硒，硒是一种具有抗癌特性的微量元素，对人类营养和健康非常重要。硒生物利用度增加的最可靠生物学参数是红细胞谷胱甘肽过氧化物酶的活性。由于银屑病是一种增殖性皮肤病，对35名患有银屑病的丹麦人、25名当地长期酒店工作人员以及34名饮用低硒水的志愿者进行了该酶活性的检测。银屑病患者在艾因-布凯克停留四周期间，其谷胱甘肽过氧化物酶活性显著增加。酒店工作人员的红细胞谷胱甘肽过氧化物酶活性比饮用低硒水的健康志愿者高50%。由此提出了硒在银屑病中可能发挥的作用。
