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Sprouty 1蛋白在人类口腔鳞状细胞癌发生过程中的过表达。

Overexpression of sprouty 1 protein in human oral squamous cell carcinogenesis.

作者信息

Wang Yen-Yun, Wang Wen-Chen, Su Chiang-Wei, Hsu Ching-Wei, Yuan Shyng-Shiou, Chen Yuk-Kwan

机构信息

School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

出版信息

J Dent Sci. 2021 Jan;16(1):21-28. doi: 10.1016/j.jds.2020.07.013. Epub 2020 Aug 18.

DOI:10.1016/j.jds.2020.07.013
PMID:33384774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7770302/
Abstract

ABSTRACT BACKGROUND/PURPOSE: Sprouty (SPRY) has four isoforms, SPRY1-4, and its deficiency produces haphazard 'sprouting' of tracheal tubules. This study investigated SPRY1 protein expression in human oral potentially malignant disorders (OPMDs) and oral squamous cell carcinomas (OSCCs).

MATERIALS AND METHODS

90 OSCCs, 10 OPMDs with malignant transformation (MT), 17 OPMDs without MT, and six normal oral mucosa (NOM) tissue samples were subjected to immunohistochemical staining. Three human oral cancer cell lines (OCCLs), an oral precancer cell line (DOK), and a primary culture of normal oral keratinocytes (HOK) were used for western blotting.

RESULTS

Significantly increased expression of SPRY1 protein from NOM and OPMD without MT to OSCC was observed. The protein expressions of SPRY1 in OCCLs were significantly enhanced as compared with DOK and HOK. Increased phosphor/total-ERK expression was observed in OCCLs as compared with HOK. A significantly increased SPRY1 protein level was noted in OPMDs with MT as compared with those without MT, in addition to a significant increase in DOK in comparison with HOK.

CONCLUSION

Our results indicated that overexpression of SPRY1 protein is potentially associated with human oral squamous cell carcinogenesis.

摘要

摘要 背景/目的：Sprouty（SPRY）有四种亚型，即SPRY1 - 4，其缺乏会导致气管小管出现杂乱的“出芽”现象。本研究调查了SPRY1蛋白在人类口腔潜在恶性病变（OPMD）和口腔鳞状细胞癌（OSCC）中的表达情况。

材料与方法

对90例OSCC、10例发生恶性转化（MT）的OPMD、17例未发生MT的OPMD以及6例正常口腔黏膜（NOM）组织样本进行免疫组织化学染色。使用三种人类口腔癌细胞系（OCCL）、一种口腔癌前细胞系（DOK）以及原代培养的正常口腔角质形成细胞（HOK）进行蛋白质免疫印迹分析。

结果

观察到从NOM和未发生MT的OPMD到OSCC，SPRY1蛋白表达显著增加。与DOK和HOK相比，OCCL中SPRY1的蛋白表达显著增强。与HOK相比，OCCL中磷酸化/总细胞外信号调节激酶（ERK）的表达增加。与未发生MT的OPMD相比，发生MT的OPMD中SPRY1蛋白水平显著增加，此外，与HOK相比，DOK中SPRY1蛋白水平也显著增加。

结论

我们的结果表明，SPRY1蛋白的过表达可能与人类口腔鳞状细胞癌的发生有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/f3486b03b4ed/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/bece23875f97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/162026fa8f3d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/72d6788a0412/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/01e60d5ec504/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/f3486b03b4ed/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/bece23875f97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/162026fa8f3d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/72d6788a0412/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/01e60d5ec504/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9fa/7770302/f3486b03b4ed/gr5.jpg

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