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口腔白斑病与口腔鳞状细胞癌中血小板源性生长因子受体α表达的比较：一项免疫组织化学研究。 （注：原文中是Podoplanin，译文里前面误写成血小板源性生长因子受体α，正确译文应为：口腔白斑病与口腔鳞癌中足板蛋白表达的比较：一项免疫组化研究。）

A Comparison of Podoplanin Expression in Oral Leukoplakia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.

作者信息

Srinivasan Vaishnavi, Shyam Ndvn, Kumar G Kiran, Narayen Vaishali, Konda Paremala, Swetha Rani Korra

机构信息

Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, IND.

出版信息

Cureus. 2023 May 2;15(5):e38467. doi: 10.7759/cureus.38467. eCollection 2023 May.

DOI:10.7759/cureus.38467
PMID:37273383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10238285/
Abstract

INTRODUCTION

Oral squamous cell carcinoma (OSCC) accounts for about 90% to 95% of all malignancies of the oral cavity.The majority of OSCCs are preceded by oral potentially malignant disorders (OPMDs). Podoplanin (PDPN) is a mucin-like small transmembrane glycoprotein. Alterations in PDPN immunoexpression have been reported in OPMDs and OSCCs.

OBJECTIVE

The objectives of this study were to evaluate the role of PDPN immunoexpression in oral leukoplakia (OL) and different histological grades of OSCC and to assess the role of PDPN as a potential biomarker for predicting the risk of malignant transformation.

MATERIALS AND METHODOLOGY

Immunohistochemical analysis for PDPN was performed in 45 histologically confirmed cases of formalin-fixed, paraffin-embedded specimens of different grades of OSCCs and 15 cases of OLs with 15 cases of the normal oral mucosa (NOM) as controls. The expression and distribution of this marker were analyzed in these lesions.

RESULTS

The immunoexpression of PDPN showed a significant increase in the expression of the percentage of positive cells, staining intensity, location of staining in the epithelium, tumor islands, and within the cells, as well as the mean lymphatic micro vessel density between NOMs, OLs, and different grades of OSCCs.

CONCLUSION

Upregulation of PDPN can be related to the malignant transformation of OLs and biological aggressiveness of OSCCs. The enhanced immunoexpression of PDPN signifies that this immunomarker can have a role in tumor cell differentiation and the neoplastic progression of OSCCs. Increased density of lymphatic vessels suggested an important role of lymphangiogenesis in tumor progression and also as a prognostic factor for lymph nodal metastasis.

摘要

引言

口腔鳞状细胞癌（OSCC）约占口腔所有恶性肿瘤的90%至95%。大多数OSCC之前都有口腔潜在恶性疾病（OPMD）。血小板源性生长因子（PDPN）是一种黏蛋白样小跨膜糖蛋白。在OPMD和OSCC中已报道PDPN免疫表达的改变。

目的

本研究的目的是评估PDPN免疫表达在口腔白斑（OL）和不同组织学分级的OSCC中的作用，并评估PDPN作为预测恶性转化风险的潜在生物标志物的作用。

材料与方法

对45例经组织学证实的不同分级OSCC的福尔马林固定、石蜡包埋标本以及15例OL进行PDPN免疫组化分析，以15例正常口腔黏膜（NOM）作为对照。分析这些病变中该标志物的表达和分布。

结果

PDPN的免疫表达显示，在阳性细胞百分比、染色强度、上皮、肿瘤岛和细胞内的染色位置以及NOM、OL和不同分级OSCC之间的平均淋巴管微血管密度方面，表达均显著增加。

结论

PDPN的上调可能与OL的恶性转化和OSCC的生物学侵袭性有关。PDPN免疫表达增强表明该免疫标志物在肿瘤细胞分化和OSCC的肿瘤进展中可能起作用。淋巴管密度增加表明淋巴管生成在肿瘤进展中起重要作用，也是淋巴结转移的预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/631a11918914/cureus-0015-00000038467-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/c0e1ae669573/cureus-0015-00000038467-i01.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/074ef2f01f6f/cureus-0015-00000038467-i03.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/7e3a7e1d41ee/cureus-0015-00000038467-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/a82d8ca4e253/cureus-0015-00000038467-i06.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/8b402487ade6/cureus-0015-00000038467-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/631a11918914/cureus-0015-00000038467-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/c0e1ae669573/cureus-0015-00000038467-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/7326cbe71454/cureus-0015-00000038467-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/074ef2f01f6f/cureus-0015-00000038467-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/10f463326532/cureus-0015-00000038467-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/7e3a7e1d41ee/cureus-0015-00000038467-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/a82d8ca4e253/cureus-0015-00000038467-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/640e2c771881/cureus-0015-00000038467-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/4a0852200d75/cureus-0015-00000038467-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/8b402487ade6/cureus-0015-00000038467-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/10238285/631a11918914/cureus-0015-00000038467-i10.jpg

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