Liu Qian, Li Mao, Wang Shiyi, Xiao Zhousheng, Xiong Yuanyuan, Wang Guangwei
Key Laboratory of Brain and Neuroendocrine Diseases, College of Hunan Province, Hunan University of Medicine, Huaihua, China.
Biomedical Research Center, Hunan University of Medicine, Huaihua, China.
Front Cell Dev Biol. 2020 Dec 15;8:601224. doi: 10.3389/fcell.2020.601224. eCollection 2020.
With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis for maintaining bone health. Osterix (Osx) has long been known to be an essential transcription factor for the osteoblast differentiation and bone mineralization. Emerging evidence suggests that Osx not only plays an important role in intramembranous bone formation, but also affects endochondral ossification by participating in the terminal cartilage differentiation. Given its essentiality in skeletal development and bone formation, Osx has become a new research hotspot in recent years. In this review, we focus on the progress of Osx's function and its regulation in osteoblast differentiation and bone mass. And the potential role of Osx in developing new therapeutic strategies for osteolytic diseases was discussed.
随着预期寿命的增加，越来越多的患者因剧烈运动或其他与骨骼相关的疾病而发生骨折。成骨细胞介导的骨形成与破骨细胞介导的骨吸收之间的平衡是维持骨骼健康的基础。长期以来，人们一直认为osterix（Osx）是成骨细胞分化和骨矿化的重要转录因子。新出现的证据表明，Osx不仅在膜内骨形成中起重要作用，还通过参与终末软骨分化影响软骨内成骨。鉴于其在骨骼发育和骨形成中的重要性，Osx近年来已成为一个新的研究热点。在这篇综述中，我们重点关注Osx在成骨细胞分化和骨量方面的功能进展及其调控。并讨论了Osx在开发溶骨性疾病新治疗策略中的潜在作用。
