Sluiter W, van Hemsbergen-Oomens L W, Elzenga-Claasen I, Annema A, van Furth R
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Exp Hematol. 1988 Feb;16(2):93-6.
Upon ingestion of particulate and soluble material, at the site of an inflammation macrophages release the factor increasing monocytopoiesis (FIM), which accelerates the rate of division of the monoblasts and promonocytes in the bone marrow. It is not known, however, whether FIM is released by macrophages present at noninflamed sites. Since FIM is secreted only during phagocytosis and alveolar macrophages ingest surfactant in vivo, the present study was performed to find out whether surfactant induces the release of FIM by alveolar macrophages. Resident alveolar macrophages were found to contain FIM and secrete this factor in vitro in the absence of an introduced phagocytable particle. Resident peritoneal macrophages also contained FIM and released this factor after exposure to surfactant. These findings suggest that in the absence of an inflammatory stimulus in vivo, alveolar macrophages that have ingested surfactant release FIM to maintain the normal production of monocytes in the bone marrow.
摄入颗粒性和可溶性物质后，在炎症部位巨噬细胞释放增加单核细胞生成的因子（FIM），该因子可加速骨髓中单核母细胞和前单核细胞的分裂速率。然而，尚不清楚FIM是否由非炎症部位的巨噬细胞释放。由于FIM仅在吞噬作用期间分泌，且肺泡巨噬细胞在体内摄取表面活性剂，因此进行本研究以确定表面活性剂是否诱导肺泡巨噬细胞释放FIM。发现驻留肺泡巨噬细胞含有FIM，并在无引入的可吞噬颗粒的情况下在体外分泌该因子。驻留腹膜巨噬细胞也含有FIM，并在暴露于表面活性剂后释放该因子。这些发现表明，在体内无炎症刺激的情况下，摄入表面活性剂的肺泡巨噬细胞释放FIM以维持骨髓中单核细胞的正常生成。
