Department of Medicine, Makunda Christian Leprosy and General Hospital, Assam, India.
Department of Pediatrics, Makunda Christian Leprosy and General Hospital, Assam, India.
Ann N Y Acad Sci. 2021 Aug;1498(1):96-107. doi: 10.1111/nyas.14552. Epub 2020 Dec 31.
In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies.
在这篇文章中，我们报告了在印度东北部一个偏远农村传教医院看到的不同形式的硫胺素缺乏症表现，包括调查、治疗和康复。详细描述了两个病例研究，一个是患有心脏脚气病的婴儿，另一个是非酒精性成年人表现为周围神经病、心肌病和代谢性酸中毒，对硫胺素补充有反应。我们分享了过去二十年来对这些临床实体的经验，包括最近的研究和经验教训，并提出了识别印度东北部高危人群、改善早期诊断和治疗以及促进预防公共卫生策略的方法。
