Shiraki K, Miyazaki S, Shimo-oku M
Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan.
Exp Neurol. 1988 Feb;99(2):342-52. doi: 10.1016/0014-4886(88)90152-5.
The effects of visual deprivation (dark-rearing) on neurons in both the visual and oculomotor systems of black mice were studied using morphologic and histochemical techniques. In the neurons of the dorsal nucleus of the lateral geniculate body, the cytoplasm of dark-reared mice was less developed and the cytoplasm/nucleus ratio was significantly smaller in the dark-reared mice than in the controls. In contrast, large motoneurons in the oculomotor nucleus did not show any ultrastructural changes and the cytoplasm/nucleus ratio was normal. However, in large motoneurons of dark-reared mice, acetylcholinesterase (AChE)-positive areas were scattered in the cytoplasm, and the ratio of the AChE-positive areas to the cytoplasm area was significantly smaller than that in the controls.
采用形态学和组织化学技术研究了视觉剥夺（暗饲养）对黑小鼠视觉和动眼系统神经元的影响。在外侧膝状体背核的神经元中，暗饲养小鼠的细胞质发育较差，暗饲养小鼠的细胞质/细胞核比值显著低于对照组。相比之下，动眼神经核中的大型运动神经元未显示任何超微结构变化，细胞质/细胞核比值正常。然而，在暗饲养小鼠的大型运动神经元中，乙酰胆碱酯酶（AChE）阳性区域散在于细胞质中，AChE阳性区域与细胞质区域的比值显著低于对照组。
