Geisert E E
J Comp Neurol. 1987 Jan 15;255(3):416-24. doi: 10.1002/cne.902550308.
When a kitten is reared with one eyelid sutured closed, there are profound changes in the developing visual system. In the lateral geniculate nucleus, the neurons in the laminae innervated by the deprived eye are smaller than normal, and some of these neurons may lose connections with the visual cortex. In the present study a variety of double label retrograde transport methods were used to define the effects of monocular deprivation on cortical projections of geniculate neurons. One marker was injected into area 17 and the other was injected into area 18. Neurons projecting to area 17 are on average 16.4% smaller than those in the nondeprived laminae. The neurons that normally would project to both areas 17 and 18 by an axon that branches are the most severely affected by monocular deprivation. These cells are nearly 40% smaller than their counterparts in the nondeprived laminae, and many of the neurons appear to lose their projection to one of the cortical areas. These neurons may be at a distinct disadvantage, since they must compete with neurons from the nondeprived laminae for a considerable amount of cortical territory in two different cortical areas. This competition may be so severe that some of the neurons are no longer capable of maintaining connections with both cortical areas.
当小猫在一只眼睑被缝合闭合的情况下饲养时，发育中的视觉系统会发生深刻变化。在外侧膝状核中，由被剥夺眼支配的板层中的神经元比正常情况下小，并且其中一些神经元可能会与视觉皮层失去联系。在本研究中，使用了多种双标记逆行运输方法来确定单眼剥夺对膝状神经元皮层投射的影响。一种标记物被注入17区，另一种被注入18区。投射到17区的神经元平均比未被剥夺的板层中的神经元小16.4%。那些正常情况下通过分支轴突投射到17区和18区的神经元受单眼剥夺的影响最为严重。这些细胞比未被剥夺的板层中的对应细胞小近40%，并且许多神经元似乎失去了对其中一个皮层区域的投射。这些神经元可能处于明显的劣势，因为它们必须在两个不同的皮层区域与来自未被剥夺板层的神经元竞争相当数量的皮层区域。这种竞争可能非常激烈，以至于一些神经元不再能够与两个皮层区域都保持联系。
