孕期大鼠肺和胎盘的15-羟基前列腺素脱氢酶

Pulmonary and placental 15-hydroxyprostaglandin dehydrogenase in rat during pregnancy.

作者信息

Tsuruta K, Mori N

机构信息

Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1988 Jan;27(1):71-9. doi: 10.1016/s0028-2243(88)80013-3.

DOI:10.1016/s0028-2243(88)80013-3

PMID:3338612

Abstract

15-Hydroxyprostaglandin dehydrogenase (PGDH) in rat lung and placenta during pregnancy was examined using a photometric assay. Pulmonary PGDH activity varied slightly during pregnancy, being significantly higher on days 10 and 19 of gestation than on day 22. Placental PGDH activity changed strikingly according to the day of pregnancy. Activity was relatively high on day 10 of gestation, fell to a low level on day 15, then increased to a maximum on day 22. A rapid fall in pulmonary PGDH activity and a remarkable increase of placental PGDH activity occurred on the day just before parturition. The results suggest that pulmonary and placental PGDH activity may cooperatively contribute to the continuity of pregnancy, and the process of parturition.

摘要

采用光度测定法检测了妊娠期间大鼠肺和胎盘中的15-羟基前列腺素脱氢酶（PGDH）。肺PGDH活性在妊娠期间略有变化，妊娠第10天和第19天显著高于第22天。胎盘PGDH活性根据妊娠天数有显著变化。妊娠第10天活性相对较高，第15天降至低水平，然后在第22天升至最高。分娩前一天肺PGDH活性迅速下降，胎盘PGDH活性显著增加。结果表明，肺和胎盘PGDH活性可能共同有助于维持妊娠的连续性及分娩过程。