Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.
Int Ophthalmol. 2021 Apr;41(4):1283-1289. doi: 10.1007/s10792-020-01686-w. Epub 2021 Jan 2.
To evaluate effects of glaucoma and central corneal thickness (CCT) on optic nerve head biomechanics.
Four groups were formed according to CCT measurements and the presence of glaucoma. Glaucomatous patients with thin (< 510 µ) and thick (> 570 µ) corneas composed groups 1 and 3, respectively. Nonglaucomatous patients with thin and thick corneas composed groups 2 and 4, respectively. Real-time elastography (RTE) was performed on all groups, and optic nerve strain rate (ONSR), orbital fat strain rate (OFSR), and strain ratio of orbital fat to the optic nerve and medial and lateral parts of the optic nerve (SROFON, SROFMON, SROFLON, respectively) were obtained and compared between groups. The correlations between CCT and these parameters were also investigated.
Statistically significant difference was not found between groups in terms of strain rate of optic nerve and orbital fat, SRFON, SROFMON and SROFLON. There was a positive correlation between ONSR and OFSR and mean CCT in patients with CCT thinner than 510 µ (p: 0.03 r: 0.26, p: 0.01 r: 0.32 respectively).
SROFON, SROFLON and SROFMON values did not differ between glaucomatous and nonglaucomatous patients with thin or thick CCTs. The correlations between CCT and OFSR and ONSR were found to be statistically significant in patients with thin CCT.
评估青光眼和中央角膜厚度（CCT）对视神经头生物力学的影响。
根据 CCT 测量值和青光眼的存在将患者分为 4 组。薄角膜（<510 µm）和厚角膜（>570 µm）的青光眼患者分别组成第 1 组和第 3 组。薄角膜和厚角膜的非青光眼患者分别组成第 2 组和第 4 组。对所有组进行实时弹性成像（RTE），并比较各组视神经应变率（ONSR）、眶脂应变率（OFSR）以及眶脂与视神经和视神经内外侧的应变比（SROFON、SROFMON、SROFLON）。还研究了 CCT 与这些参数之间的相关性。
在薄 CCT（<510 µm）患者中，ONSR 和 OFSR 与平均 CCT 之间存在正相关（p：0.03 r：0.26，p：0.01 r：0.32），但各组之间视神经和眶脂的应变率、SRFON、SROFMON 和 SROFLON 无统计学差异。
薄 CCT 的青光眼和非青光眼患者之间 SROFON、SROFLON 和 SROFMON 值无差异。在 CCT 较薄的患者中，CCT 与 OFSR 和 ONSR 之间的相关性具有统计学意义。
