Chansangpetch Sunee, Panpruk Rawiphan, Manassakorn Anita, Tantisevi Visanee, Rojanapongpun Prin, Hurst Cameron P, Lin Shan C
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Department of Ophthalmology, University of California, San Francisco Medical School, San Francisco, California, United States.
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):4990-4996. doi: 10.1167/iovs.17-22219.
We evaluated the impact of myopia on corneal biomechanical properties in primary open-angle glaucoma (POAG) and nonglaucoma patients, and the effect of modification of glaucoma on myopic eyes.
This cross-sectional study included 66 POAG eyes (33 myopia, 33 nonmyopia) and 66 normal eyes (33 myopia, 33 nonmyopia). Seven corneal biomechanical parameters were measured by ultra-high-speed Scheimpflug imaging, including corneal deformation amplitude (CDA), inward/outward corneal applanation length (ICA, OCA), inward/outward corneal velocity (ICV, OCV), radius, and peak distance (PD).
Mean age (SD) of the 65 male (49%) and 67 female (51%) patients was 59 (9.82) years. Myopia was associated with significantly higher CDA (adjusted effect = 0.104, P = 0.001) and lower OCV (adjusted effect = -0.105, P < 0.001) in the POAG group. Within the nonglaucoma group, myopic eyes had a significantly lower OCV (adjusted effect = -0.086, P < 0.001) and higher CDA (adjusted effect = 0.079, P = 0.001). All parameters except PD suggested that glaucoma modified the effect of myopia on corneal biomechanics. Percentage differences in the adjusted myopic effect between POAG and nonglaucoma patients was 31.65, 27.27, 31.65, 50.00, 22.09, and 60.49 for CDA, ICA, OCA, ICV, OCV, and radius, respectively.
Myopia had a significant impact on corneal biomechanical properties in the POAG and nonglaucoma groups. The differences in corneal biomechanical parameters suggest that myopia is correlated with significantly lower ocular rigidity. POAG may enhance the effects of myopia on most of these parameters.
我们评估了近视对原发性开角型青光眼（POAG）患者和非青光眼患者角膜生物力学特性的影响，以及青光眼病情变化对近视眼的影响。
这项横断面研究纳入了66只POAG患眼（33只近视，33只非近视）和66只正常眼（33只近视，33只非近视）。通过超高速Scheimpflug成像测量七个角膜生物力学参数，包括角膜变形幅度（CDA）、角膜向内/向外压平长度（ICA、OCA）、角膜向内/向外速度（ICV、OCV）、半径和峰值距离（PD）。
65名男性（49%）和67名女性（51%）患者的平均年龄（标准差）为59（9.82）岁。在POAG组中，近视与显著更高的CDA（校正效应=0.104，P=0.001）和更低的OCV（校正效应=-0.105，P<0.001）相关。在非青光眼组中，近视眼的OCV显著更低（校正效应=-0.086，P<0.001），CDA更高（校正效应=0.079，P=0.001）。除PD外，所有参数均表明青光眼改变了近视对角膜生物力学的影响。POAG患者和非青光眼患者之间校正后近视效应的百分比差异，CDA、ICA、OCA、ICV、OCV和半径分别为31.65、27.27、31.65、50.00、22.09和60.49。
近视对POAG组和非青光眼组的角膜生物力学特性有显著影响。角膜生物力学参数的差异表明，近视与显著更低的眼硬度相关。POAG可能会增强近视对这些参数中大多数的影响。
