Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, NO 300. Guangzhou Road, Nanjing, 210029, China.
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, No 300, Guangzhou Road, Nanjing, 210029, China.
J Thromb Thrombolysis. 2021 Jul;52(1):324-330. doi: 10.1007/s11239-020-02363-6. Epub 2021 Jan 2.
The coagulation factor VII (FVII) gene R353Q polymorphism is suggested to be relevant to the coronary heart disease (CHD) susceptibility. However, the results of separate studies are not consistent with one another. A meta-analysis including 3258 participants from nine studies was conducted to investigate the relationship between the FVII gene R353Q polymorphism and the CHD in the Chinese population. The fixed-effect models were used to assess the pooled odds ratios (ORs) and their corresponding 95% confidence intervals. A significant association was observed between the FVII gene R353Q polymorphism and the CHD in the Chinese population under allelic (OR 1.34, 95% CI 1.10-1.65, P = 0.004), dominant (OR 0.68, 95% CI 0.55-0.85, P = 0.0006), and heterozygous (OR 0.68, 95% CI 0.55-0.85, P = 0.0007) genetic models. The FVII gene R353Q polymorphism was significantly correlated with the CHD susceptibility in the Chinese population. Persons with the R allele of the FVII gene R353Q polymorphism might have greater CHD risk than others.
凝血因子 VII（FVII）基因 R353Q 多态性与冠心病（CHD）易感性有关。然而，单独研究的结果并不一致。对来自 9 项研究的 3258 名参与者进行了荟萃分析，以研究 FVII 基因 R353Q 多态性与中国人群 CHD 的关系。采用固定效应模型评估合并优势比（OR）及其相应的 95%置信区间。在中国人中，FVII 基因 R353Q 多态性与 CHD 之间存在显著关联，在等位基因（OR 1.34，95%CI 1.10-1.65，P=0.004）、显性（OR 0.68，95%CI 0.55-0.85，P=0.0006）和杂合子（OR 0.68，95%CI 0.55-0.85，P=0.0007）遗传模型下。FVII 基因 R353Q 多态性与中国人 CHD 的易感性显著相关。FVII 基因 R353Q 多态性 R 等位基因的个体患 CHD 的风险可能大于其他个体。
